The work described herein represents a continuation of our efforts on the synthesis of antitumor agents. We describe the targeted completion of the cytotoxic diterpene shikodonin. Some methodology developed during the course of these efforts will be highlighted via a projected synthesis of the antibiotic udoteatrial. Considerable energy will be targeted at continuing efforts initiated during the course of the shikodonin synthesis that involved the elucidation of the structure-reactivity relationships in azaallyllithium derivatives.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM030350-05
Application #
3278056
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1982-02-01
Project End
1990-01-31
Budget Start
1986-02-01
Budget End
1987-01-31
Support Year
5
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Cornell University
Department
Type
Schools of Arts and Sciences
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850