Abstract

This research program uses a unique set of methods to study the influence of intrapartum analgesic administration on infant behavioral development in a suitable animal model, the rhesus monkey. For the proposed research, this model will be expanded by including methods for epidural drug administration during labor, assessment of plasma protein drug binding patterns, and induction of intrapartum hypoxia. Problems to be addressed are: (1) the infant behavioral effects of epidural analgesia/anesthesia (bupivacaine and meperidine); (2) the influence of differential fetal-maternal protein binding on fetal drug exposure; (3) the interaction of narcotic analgesics with intrapartum hypoxia. In addition, we will continue characterization of the endogenous opiate system in the perinatal period to aid in understanding the effects of opiate analgesics. Finally, some parallel studies will be conducted in guinea pigs to extend the capability for investigation of these research problems to a more accessible and economical animal model. Basic research in animal models can provide both the conceptual and empirical framework for continued advances in development of safe and effective obstetric analgesia practices.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM032920-07
Application #
3282150
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1984-01-01
Project End
1994-11-30
Budget Start
1991-12-01
Budget End
1992-11-30
Support Year
7
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of California Davis
Department
Type
Schools of Veterinary Medicine
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Golub, M S; Germann, S L (1998) Perinatal bupivacaine and infant behavior in rhesus monkeys. Neurotoxicol Teratol 20:29-41
Golub, M S; Kaaekuahiwi, M A; Eisele, P H et al. (1998) Newborn tissue concentrations of bupivacaine following maternal epidural administration during labor in guinea pigs. Biol Neonate 74:304-13
Golub, M S (1996) Labor analgesia and infant brain development. Pharmacol Biochem Behav 55:619-28
DeWeert, T M; Golub, M S; Kaaekuahiwi, M A (1995) Long-term epidural catheterization of rhesus macaques: loss of resistance technique. Lab Anim Sci 45:94-7
Golub, M S; Donald, J M (1995) Effect of intrapartum meperidine on behavior of 3- to 12-month-old infant rhesus monkeys. Biol Neonate 67:140-8
Golub, M S; Kaaekuahiwi, M A (1995) Response to maternal separation in infant guinea pigs exposed to intrapartum meperidine. Dev Psychobiol 28:59-68
Eisele, P H; Kaaekuahiwi, M A; Canfield, D R et al. (1994) Epidural catheter placement for testing of obstetrical analgesics in female guinea pigs. Lab Anim Sci 44:486-90
Golub, M S; Eisele Jr, J H; Donald, J M (1991) Effect of intrapartum meperidine on the behavioral consequences of neonatal oxygen deprivation in rhesus monkey infants. Dev Pharmacol Ther 16:231-40
Golub, M S (1990) Use of monkey neonatal neurobehavioral test batteries in safety testing protocols. Neurotoxicol Teratol 12:537-41
Golub, M S; Eisele Jr, J H; Hwang, F Y et al. (1989) Late-pregnancy changes in peripheral plasma beta-endorphin in rhesus monkeys (Macaca mulatta). Gynecol Obstet Invest 27:113-7

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