We have developed new synthetic methods which we will apply to the total synthesis of the antineoplastic agent daunomycin. Plans for the total synthesis of cytotoxic sesquiterpene lactones damsin, helenalin and quadrone are also presented. In the sesquiterpene related work, we will develop a method of carbocyclic ring synthesis that is functionally equivalent to an intramolecular Diels-Alder reaction between a carbene and a diene system. Model studies will feature an efficient, stereospecific total synthesis of the sesquiterpene longifolene.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM033061-12
Application #
3282411
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1978-09-01
Project End
1991-11-30
Budget Start
1989-12-01
Budget End
1990-11-30
Support Year
12
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Rensselaer Polytechnic Institute
Department
Type
Schools of Arts and Sciences
DUNS #
002430742
City
Troy
State
NY
Country
United States
Zip Code
12180