Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM033376-02
Application #
3283042
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1985-04-01
Project End
1988-03-31
Budget Start
1986-04-01
Budget End
1987-03-31
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Louisville
Department
Type
Schools of Arts and Sciences
DUNS #
City
Louisville
State
KY
Country
United States
Zip Code
40292
Burden, John E; Davis, Peg; Porreca, Frank et al. (2002) Synthesis and biological activities of YkFA analogues: effects of position 4 substitutions and altered ring size on in vitro opioid activity. Bioorg Med Chem Lett 12:213-6
Burden, J E; Davis, P; Porreca, F et al. (1999) Synthesis and biological activities of position one and three transposed analogs of the opioid peptide YKFA. Bioorg Med Chem Lett 9:3441-6
Romanovskis, P; Spatola, A F (1998) Preparation of head-to-tail cyclic peptides via side-chain attachment: implications for library synthesis. J Pept Res 52:356-74
Crozet, Y; Wen, J J; Loo, R O et al. (1997) Synthesis and characterization of cyclic pseudopeptide libraries containing thiomethylene and thiomethylene-sulfoxide amide bond surrogates. Mol Divers 3:261-76
Wen, J J; Spatola, A F (1997) A systematic approach to the solid-phase synthesis of linear and cyclic pseudopeptide libraries containing psi[CH2NH] amide bond surrogates. J Pept Res 49:3-14
Spatola, A F; Crozet, Y (1996) Rediscovering an endothelin antagonist (BQ-123): a self-deconvoluting cyclic pentapeptide library. J Med Chem 39:3842-6
Ma, S; Richardson, J F; Spatola, A F (1993) Crystal structures of two cyclic pseudopentapeptides containing psi[CH2S] and psi[CH2SO] backbone surrogates. Biopolymers 33:1101-10
Ma, S; Spatola, A F (1993) Conformations of psi [CH2NH] pseudopeptides. Cyclo[Gly-Pro psi [CH2NH]Gly-D-Phe-Pro]-TFA and cyclo[Gly-Pro psi [CH2NH]Gly-D-Phe-Pro] Int J Pept Protein Res 41:204-6
Spatola, A F; Anwer, M K; Rao, M N (1992) Phase transfer catalysis in solid phase peptide synthesis. Preparation of cyclo[Xxx-Pro-Gly-Yyy-Pro-Gly] model peptides and their conformational analysis. Int J Pept Protein Res 40:322-32
Grzonka, Z; Kasprzykowski, F; Lubkowska, L et al. (1991) In vitro degradation of some arginine-vasopressin analogs by homogenates of rat kidney, liver and serum. Pept Res 4:270-4

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