Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM033464-05S1
Application #
3283219
Study Section
Biochemistry Study Section (BIO)
Project Start
1985-07-01
Project End
1992-06-30
Budget Start
1990-01-01
Budget End
1990-06-30
Support Year
5
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Penning, T M; Thronton, R; Ricigliano, J W (1991) Clues to the development of mechanism-based inactivators of 3 alpha-hydroxysteroid dehydrogenase: comparison of steroidal and nonsteroidal Michael acceptors and epoxides. Steroids 56:420-7
Penning, T M; Ricigliano, J W (1991) Mechanism based inhibition of hydroxysteroid dehydrogenases. J Enzyme Inhib 5:165-98
Hardy, M P; Gelber, S J; Zhou, Z F et al. (1991) Hormonal control of Leydig cell differentiation. Ann N Y Acad Sci 637:152-63
Pawlowski, J; Huizinga, M; Penning, T M (1991) Isolation and partial characterization of a full-length cDNA clone for 3 alpha-hydroxysteroid dehydrogenase: a potential target enzyme for nonsteroidal anti-inflammatory drugs. Agents Actions 34:289-93
Penning, T M; Abrams, W R; Pawlowski, J E (1991) Affinity labeling of 3 alpha-hydroxysteroid dehydrogenase with 3 alpha-bromoacetoxyandrosterone and 11 alpha-bromoacetoxyprogesterone. Isolation and sequence of active site peptides containing reactive cysteines;sequence confirmation using nucleotide sequ J Biol Chem 266:8826-34
Pawlowski, J E; Huizinga, M; Penning, T M (1991) Cloning and sequencing of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. J Biol Chem 266:8820-5
Ricigliano, J W; Penning, T M (1990) Evidence that enzyme-generated aromatic Michael acceptors covalently modify the nucleotide-binding site of 3 alpha-hydroxysteroid dehydrogenase. Biochem J 269:749-55
Ricigliano, J W; Penning, T M (1989) Synthesis and evaluation of non-steroidal mechanism-based inactivators of 3 alpha-hydroxysteroid dehydrogenase. Biochem J 262:139-49
Smithgall, T E; Penning, T M (1988) Electrophoretic and immunochemical characterization of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenases of rat tissues. Biochem J 254:715-21
Penning, T M; Carlson, K E; Sharp, R B (1987) Affinity-labelling of the anti-inflammatory drug and prostaglandin-binding site of 3 alpha-hydroxysteroid dehydrogenase of rat liver cytosol with 17 beta- and 21-bromoacetoxysteroids. Biochem J 245:269-76

Showing the most recent 10 out of 15 publications