Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM034205-03S1
Application #
3284777
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1984-12-01
Project End
1988-02-29
Budget Start
1987-12-01
Budget End
1988-02-29
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Arts and Sciences
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Gartenberg, M R; Crothers, D M (1991) Synthetic DNA bending sequences increase the rate of in vitro transcription initiation at the Escherichia coli lac promoter. J Mol Biol 219:217-30
Zinkel, S S; Crothers, D M (1991) Catabolite activator protein-induced DNA bending in transcription initiation. J Mol Biol 219:201-15
Gartenberg, M R; Ampe, C; Steitz, T A et al. (1990) Molecular characterization of the GCN4-DNA complex. Proc Natl Acad Sci U S A 87:6034-8
Straney, D C; Straney, S B; Crothers, D M (1989) Synergy between Escherichia coli CAP protein and RNA polymerase in the lac promoter open complex. J Mol Biol 206:41-57
Brown, A M; Crothers, D M (1989) Modulation of the stability of a gene-regulatory protein dimer by DNA and cAMP. Proc Natl Acad Sci U S A 86:7387-91
Ghosaini, L R; Brown, A M; Sturtevant, J M (1988) Scanning calorimetric study of the thermal unfolding of catabolite activator protein from Escherichia coli in the absence and presence of cyclic mononucleotides. Biochemistry 27:5257-61
Straney, S B; Crothers, D M (1987) Lac repressor is a transient gene-activating protein. Cell 51:699-707
Straney, D C; Crothers, D M (1987) A stressed intermediate in the formation of stably initiated RNA chains at the Escherichia coli lac UV5 promoter. J Mol Biol 193:267-78
Straney, D C; Crothers, D M (1987) Effect of drug-DNA interactions upon transcription initiation at the lac promoter. Biochemistry 26:1987-95
Straney, D C; Crothers, D M (1987) Comparison of the open complexes formed by RNA polymerase at the Escherichia coli lac UV5 promoter. J Mol Biol 193:279-92

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