Abstract

We plan to isolate, purify and determine the structures of compounds which have a direct or indirect bearing with cancer, cell growth regulation and other biological activities. If feasible the structural studies will be followed by bioorganic studies. The compounds involved include adduct resulting from binding of carcinogens to nucleic acids, various nucleic acid base derivatives, marine neurotoxins, cell growth regulators, and an antisickling agent.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM034509-19
Application #
3285654
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1985-01-01
Project End
1988-12-31
Budget Start
1988-01-01
Budget End
1988-12-31
Support Year
19
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
Graduate Schools
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027

  Publications

Chen, Yihui; Wu, Yalin; Henklein, Peter et al. (2010) A photo-cross-linking strategy to map sites of protein-protein interactions. Chemistry 16:7389-94
Sparrow, Janet R; Cai, Bolin; Jang, Young Pyo et al. (2006) A2E, a fluorophore of RPE lipofuscin, can destabilize membrane. Adv Exp Med Biol 572:63-8
Jang, Young P; Matsuda, Hiroko; Itagaki, Yasuhiro et al. (2005) Characterization of peroxy-A2E and furan-A2E photooxidation products and detection in human and mouse retinal pigment epithelial cell lipofuscin. J Biol Chem 280:39732-9
Nehira, Tatsuo; Tanaka, Katsunori; Takakuwa, Takashi et al. (2005) Development of a universal ellipsoidal mirror device for fluorescence detected circular dichroism: elimination of polarization artifacts. Appl Spectrosc 59:121-5
Balaz, Milan; Holmes, Andrea E; Benedetti, Michele et al. (2005) Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates. J Am Chem Soc 127:4172-3
Tanaka, Katsunori; Itagaki, Yasuhiro; Satake, Masayuki et al. (2005) Three challenges toward the assignment of absolute configuration of gymnocin-B. J Am Chem Soc 127:9561-70
Fishkin, Nathan E; Sparrow, Janet R; Allikmets, Rando et al. (2005) Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate. Proc Natl Acad Sci U S A 102:7091-6
Giorgio, Egidio; Roje, Marin; Tanaka, Katsunori et al. (2005) Determination of the absolute configuration of flexible molecules by ab initio ORD calculations: a case study with cytoxazones and isocytoxazones. J Org Chem 70:6557-63
Giorgio, Egidio; Tanaka, Katsunori; Ding, Weidong et al. (2005) Theoretical simulation of the electronic circular dichroism spectrum of calicheamicin. Bioorg Med Chem 13:5072-9
Jang, Young P; Zhou, Jilin; Nakanishi, Koji et al. (2005) Anthocyanins protect against A2E photooxidation and membrane permeabilization in retinal pigment epithelial cells. Photochem Photobiol 81:529-36

Showing the most recent 10 out of 63 publications