Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM035147-07
Application #
2177765
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1987-07-01
Project End
1996-10-31
Budget Start
1995-08-01
Budget End
1996-10-31
Support Year
7
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Sri International
Department
Type
DUNS #
City
Menlo Park
State
CA
Country
United States
Zip Code
94025

  Publications

Nolen 3rd, H W; Fedorak, R N; Friend, D R (1997) Steady-state pharmacokinetics of corticosteroid delivery from glucuronide prodrugs in normal and colitic rats. Biopharm Drug Dispos 18:681-95
Fedorak, R N; Haeberlin, B; Empey, L R et al. (1995) Colonic delivery of dexamethasone from a prodrug accelerates healing of colitis in rats without adrenal suppression. Gastroenterology 108:1688-99
Fedorak, R N; Cui, N; Friend, D R et al. (1995) A novel colon-specific steroid prodrug enhances sodium chloride absorption in rat colitis. Am J Physiol 269:G210-8
Nolen 3rd, H; Fedorak, R N; Friend, D R (1995) Budesonide-beta-D-glucuronide: a potential prodrug for treatment of ulcerative colitis. J Pharm Sci 84:677-81
Haeberlin, B; Rubas, W; Nolen 3rd, H W et al. (1993) In vitro evaluation of dexamethasone-beta-D-glucuronide for colon-specific drug delivery. Pharm Res 10:1553-62
Friend, D R; Phillips, S; McLeod, A et al. (1991) Relative anti-inflammatory effect of oral dexamethasone-beta-D-glucoside and dexamethasone in experimental inflammatory bowel disease in guinea-pigs. J Pharm Pharmacol 43:353-5
Tozer, T N; Rigod, J; McLeod, A D et al. (1991) Colon-specific delivery of dexamethasone from a glucoside prodrug in the guinea pig. Pharm Res 8:445-54