Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM035392-09
Application #
2177874
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1985-01-01
Project End
1996-11-30
Budget Start
1994-12-01
Budget End
1996-11-30
Support Year
9
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Purdue University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Baker, A S; Ciocci, M J; Metcalf, W W et al. (1998) Insights into the mechanism of catalysis by the P-C bond-cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis. Biochemistry 37:9305-15
Haldimann, A; Fisher, S L; Daniels, L L et al. (1997) Transcriptional regulation of the Enterococcus faecium BM4147 vancomycin resistance gene cluster by the VanS-VanR two-component regulatory system in Escherichia coli K-12. J Bacteriol 179:5903-13
Haldimann, A; Prahalad, M K; Fisher, S L et al. (1996) Altered recognition mutants of the response regulator PhoB: a new genetic strategy for studying protein-protein interactions. Proc Natl Acad Sci U S A 93:14361-6
Wanner, B L (1996) Signal transduction in the control of phosphate-regulated genes of Escherichia coli. Kidney Int 49:964-7
Metcalf, W W; Jiang, W; Daniels, L L et al. (1996) Conditionally replicative and conjugative plasmids carrying lacZ alpha for cloning, mutagenesis, and allele replacement in bacteria. Plasmid 35:1-13
Fisher, S L; Kim, S K; Wanner, B L et al. (1996) Kinetic comparison of the specificity of the vancomycin resistance VanSfor two response regulators, VanR and PhoB. Biochemistry 35:4732-40
Jiang, W; Metcalf, W W; Lee, K S et al. (1995) Molecular cloning, mapping, and regulation of Pho regulon genes for phosphonate breakdown by the phosphonatase pathway of Salmonella typhimurium LT2. J Bacteriol 177:6411-21
Fisher, S L; Jiang, W; Wanner, B L et al. (1995) Cross-talk between the histidine protein kinase VanS and the response regulator PhoB. Characterization and identification of a VanS domain that inhibits activation of PhoB. J Biol Chem 270:23143-9
Wanner, B L (1994) Molecular genetics of carbon-phosphorus bond cleavage in bacteria. Biodegradation 5:175-84
Metcalf, W W; Wanner, B L (1993) Mutational analysis of an Escherichia coli fourteen-gene operon for phosphonate degradation, using TnphoA' elements. J Bacteriol 175:3430-42

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