Abstract

The project concerns assembling chemical and ultrastructural data in order to establish the way natural products function in plants as well as their role in coevolutionary systems involving plants and animals. The investigation emphasizes the phenolics, terpenoids and alkaloids present in members of the Compositae genera Helianthus and Artemesia, as well as other genera including especially Passiflora and Salvia. The antiherbivore, antimicrobial, allergenic contact dermatitis and antitumor activity of the isolated compounds are studied. The patterns of compounds encountered are used as genetic markers to understand phylogenetic relationships. New sequiterpene lactones, diterpene acids and flavonoid aglycones and their O- and C-glycosides have been isolated and structurally characterized by UV, NMR and MS spectral data as well as chemical derivatization and transformation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM035710-22
Application #
3288770
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1985-07-10
Project End
1992-06-30
Budget Start
1988-07-01
Budget End
1989-06-30
Support Year
22
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Texas Austin
Department
Type
Schools of Arts and Sciences
DUNS #
City
Austin
State
TX
Country
United States
Zip Code
78713

  Publications

Ahmed, A A; Balboul, B A; Scott, A I et al. (1998) Eudesmane derivatives from Iva frutescens. Phytochemistry 47:411-3
Li, C J; Ahmed, A A; Arias, A C et al. (1997) Clerodane diterpenoids, long chain esters of coumaric acid and other compounds from Baccharis myrsinites. Phytochemistry 45:571-4
Ahmed, A A; Abd el-Razek, M H; Abu Mostafa, E A et al. (1996) A new derivative of glucose and 2-C-methyl-D-erythritol from Ferula sinaica. J Nat Prod 59:1171-3
Li, C J; Li, Y H; Xiao, P G et al. (1996) An unusual cycloartane triterpenoid from Cimicifuga foetida. Phytochemistry 42:489-94
Kandil, F E; el-Sayed, N H; Micheal, H N et al. (1996) Gallotannins and flavonoids from Haematoxylon campechianum. Phytochemistry 42:1243-5
Ahmed, A A; aboul Ela, M; de Adams, A A et al. (1996) Sesquiterpenes from Lepechinia urbaniana. Planta Med 62:385-6
Liu, Q; Bonness, M S; Liu, M et al. (1995) Enzymes of B-ring-deoxy flavonoid biosynthesis in elicited cell cultures of ""old man"" cactus (Cephalocereus senilis). Arch Biochem Biophys 321:397-404
Ahmed, A A; Hussein, N S; De Adams, A A et al. (1995) Abietane diterpenes from Lepechinia urbaniana. Pharmazie 50:279-80
Ahmed, A A; Spring, O; el-Razek, M H et al. (1995) Sesquiterpene lactones and other constituents from Hymenoxys richardsonii and H. subintegra. Phytochemistry 39:1127-31
Liu, Q; Liu, M; Mabry, T J et al. (1994) Flavonol glycosides from Cephalocereus senilis. Phytochemistry 36:229-31

Showing the most recent 10 out of 23 publications