Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM035889-01S1
Application #
3289269
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1986-12-01
Project End
1991-08-31
Budget Start
1986-12-01
Budget End
1987-08-31
Support Year
1
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Virginia
Department
Type
Schools of Arts and Sciences
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904

  Publications

Wagner, T; Kretsinger, R H; Bauerle, R et al. (2000) 3-Deoxy-D-manno-octulosonate-8-phosphate synthase from Escherichia coli. Model of binding of phosphoenolpyruvate and D-arabinose-5-phosphate. J Mol Biol 301:233-8
Wagner, T; Shumilin, I A; Bauerle, R et al. (2000) Structure of 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from Escherichia coli: comparison of the Mn(2+)*2-phosphoglycolate and the Pb(2+)*2-phosphoenolpyruvate complexes and implications for catalysis. J Mol Biol 301:389-99
Tolbert, W D; Chatterji, S; Bauerle, R et al. (1999) Crystallization and preliminary crystallographic studies of the anthranilate synthase partial complex from Salmonella typhimurium. Acta Crystallogr D Biol Crystallogr 55:305-6
Shumilin, I A; Kretsinger, R H; Bauerle, R H (1999) Crystal structure of phenylalanine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli. Structure 7:865-75
Park, O K; Bauerle, R (1999) Metal-catalyzed oxidation of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli: inactivation and destabilization by oxidation of active-site cysteines. J Bacteriol 181:1636-42
Akowski, J P; Bauerle, R (1997) Steady-state kinetics and inhibitor binding of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (tryptophan sensitive) from Escherichia coli. Biochemistry 36:15817-22
Shumilin, I A; Kretsinger, R H; Bauerle, R (1996) Purification, crystallization, and preliminary crystallographic analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli. Proteins 24:404-6
Tolbert, W D; Moll, J R; Bauerle, R et al. (1996) Crystallization and preliminary crystallographic studies of 3-deoxy-D-manno-octulosonate-8-phosphate synthase from Escherichia coli. Proteins 24:407-8
Morollo, A A; Bauerle, R (1993) Characterization of composite aminodeoxyisochorismate synthase and aminodeoxyisochorismate lyase activities of anthranilate synthase. Proc Natl Acad Sci U S A 90:9983-7
Stephens, C M; Bauerle, R (1992) Essential cysteines in 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli. Analysis by chemical modification and site-directed mutagenesis of the phenylalanine-sensitive isozyme. J Biol Chem 267:5762-7

Showing the most recent 10 out of 17 publications