Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM035894-04
Application #
3289282
Study Section
Virology Study Section (VR)
Project Start
1987-06-01
Project End
1990-12-31
Budget Start
1988-01-01
Budget End
1988-12-31
Support Year
4
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Duke University
Department
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Yan, D H; Weiss, E A; Nevins, J R (1995) Identification of an activity in B-cell extracts that selectively impairs the formation of an immunoglobulin mu s poly(A) site processing complex. Mol Cell Biol 15:1901-6
Mann, K P; Weiss, E A; Nevins, J R (1993) Alternative poly(A) site utilization during adenovirus infection coincides with a decrease in the activity of a poly(A) site processing factor. Mol Cell Biol 13:2411-9
Gilmartin, G M; Nevins, J R (1991) Molecular analyses of two poly(A) site-processing factors that determine the recognition and efficiency of cleavage of the pre-mRNA. Mol Cell Biol 11:2432-8
Gilmartin, G M; Nevins, J R (1989) An ordered pathway of assembly of components required for polyadenylation site recognition and processing. Genes Dev 3:2180-90
Galli, G; Guise, J; Tucker, P W et al. (1988) Poly(A) site choice rather than splice site choice governs the regulated production of IgM heavy-chain RNAs. Proc Natl Acad Sci U S A 85:2439-43
Adami, G; Nevins, J R (1988) Splice site selection dominates over poly(A) site choice in RNA production from complex adenovirus transcription units. EMBO J 7:2107-16
McDevitt, M A; Gilmartin, G M; Reeves, W H et al. (1988) Multiple factors are required for poly(A) addition to a mRNA 3' end. Genes Dev 2:588-97
Gilmartin, G M; McDevitt, M A; Nevins, J R (1988) Multiple factors are required for specific RNA cleavage at a poly(A) addition site. Genes Dev 2:578-87
Galli, G; Guise, J W; McDevitt, M A et al. (1987) Relative position and strengths of poly(A) sites as well as transcription termination are critical to membrane versus secreted mu-chain expression during B-cell development. Genes Dev 1:471-81
McDevitt, M A; Hart, R P; Wong, W W et al. (1986) Sequences capable of restoring poly(A) site function define two distinct downstream elements. EMBO J 5:2907-13