Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM036232-09S1
Application #
2178227
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1986-07-01
Project End
1995-09-29
Budget Start
1994-07-01
Budget End
1995-09-29
Support Year
9
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Wu, Fayi; Katsir, Leron J; Seavy, Margaret et al. (2003) Role of radical formation at tyrosine 193 in the allene oxide synthase domain of a lipoxygenase-AOS fusion protein from coral. Biochemistry 42:6871-80
Gaffney, B J; Su, C; Oliw, E H (2001) Assignment of EPR Transitions in a Manganese-Containing Lipoxygenase and Prediction of Local Structure. Appl Magn Reson 21:413-424
Abraham, B D; Sono, M; Boutaud, O et al. (2001) Characterization of the coral allene oxide synthase active site with UV-visible absorption, magnetic circular dichroism, and electron paramagnetic resonance spectroscopy: evidence for tyrosinate ligation to the ferric enzyme heme iron. Biochemistry 40:2251-9
Bowers, C R; Storhaug, V; Webster, C E et al. (1999) Exploring surfaces and cavities in lipoxygenase and other proteins by hyperpolarized xenon-129 NMR. J Am Chem Soc 121:9370-7
Grant, C V; Cope, W; Ball, J A et al. (1999) Electronic Structure of the Aqueous Vanadyl Ion Probed by 9 and 94 GHz EPR and Pulsed ENDOR Spectroscopies and Density Functional Theory Calculations. J Phys Chem B 103:10627-31
Gaffney, B J; Marsh, D (1998) High-frequency, spin-label EPR of nonaxial lipid ordering and motion in cholesterol-containing membranes. Proc Natl Acad Sci U S A 95:12940-3
Gaffney, B J; Silverstone, H J (1998) Simulation methods for looping transitions. J Magn Reson 134:57-66
Gaffney, B J; Eaton, G R; Eaton, S S (1998) Electron Spin Relaxation Rates for High-Spin Fe(III) in Iron Transferrin Carbonate and Iron Transferrin Oxalate. J Phys Chem B 102:5536-41
Boyington, J C; Gaffney, B J; Amzel, L M (1997) The three-dimensional structure of soybean lipoxygenase-1: an arachidonic acid 15-lipoxygenase. Adv Exp Med Biol 400A:133-8
Gaffney, B J (1996) Lipoxygenases: structural principles and spectroscopy. Annu Rev Biophys Biomol Struct 25:431-59

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