Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM036922-03
Application #
3291583
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1986-07-01
Project End
1991-06-30
Budget Start
1988-07-01
Budget End
1989-06-30
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
Schools of Pharmacy
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Iyer, K R; Jones, J P; Darbyshire, J F et al. (1997) Intramolecular isotope effects for benzylic hydroxylation of isomeric xylenes and 4,4'-dimethylbiphenyl by cytochrome P450: relationship between distance of methyl groups and masking of the intrinsic isotope effect. Biochemistry 36:7136-43
Darbyshire, J F; Iyer, K R; Grogan, J et al. (1996) Substrate probe for the mechanism of aromatic hydroxylation catalyzed by cytochrome P450. Drug Metab Dispos 24:1038-45
Carlson, T J; Jones, J P; Peterson, L et al. (1995) Stereoselectivity and isotope effects associated with cytochrome P450-catalyzed oxidation of (S)-nicotine. The possibility of initial hydrogen atom abstraction in the formation of the delta 1', 5-nicotinium ion. Drug Metab Dispos 23:749-56
Kunze, K L; Trager, W F (1993) Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline. Chem Res Toxicol 6:649-56
Korzekwa, K R; Trager, W F; Mancewicz, J et al. (1993) Studies on the mechanism of aromatase and other cytochrome P450 mediated deformylation reactions. J Steroid Biochem Mol Biol 44:367-73
Korzekwa, K R; Trager, W F; Smith, S J et al. (1991) Theoretical studies on the mechanism of conversion of androgens to estrogens by aromatase. Biochemistry 30:6155-62
Ottoboni, S; Carlson, T J; Trager, W F et al. (1990) Studies on the cytochrome P-450 catalyzed ring alpha-carbon oxidation of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Chem Res Toxicol 3:423-7
Korzekwa, K; Howald, W N; Trager, W F (1990) The use of Brauman's least squares approach for the quantification of deuterated chlorophenols. Biomed Environ Mass Spectrom 19:211-7
Korzekwa, K R; Trager, W F; Nagata, K et al. (1990) Isotope effect studies on the mechanism of the cytochrome P-450IIA1-catalyzed formation of delta 6-testosterone from testosterone. Drug Metab Dispos 18:974-9
Jones, J P; Rettie, A E; Trager, W F (1990) Intrinsic isotope effects suggest that the reaction coordinate symmetry for the cytochrome P-450 catalyzed hydroxylation of octane is isozyme independent. J Med Chem 33:1242-6

Showing the most recent 10 out of 14 publications