Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM037044-09
Application #
2178650
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1988-02-01
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1998-01-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Kansas
Department
Pharmacology
Type
Schools of Medicine
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160
LeCluyse, E; Madan, A; Hamilton, G et al. (2000) Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes. J Biochem Mol Toxicol 14:177-88
LeCluyse, E; Bullock, P; Madan, A et al. (1999) Influence of extracellular matrix overlay and medium formulation on the induction of cytochrome P-450 2B enzymes in primary cultures of rat hepatocytes. Drug Metab Dispos 27:909-15
LeCluyse, E L; Bullock, P L; Parkinson, A et al. (1996) Cultured rat hepatocytes. Pharm Biotechnol 8:121-59
Parkinson, A (1996) An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials. Toxicol Pathol 24:48-57
Pearce, R E; McIntyre, C J; Madan, A et al. (1996) Effects of freezing, thawing, and storing human liver microsomes on cytochrome P450 activity. Arch Biochem Biophys 331:145-69
Pearce, R E; Rodrigues, A D; Goldstein, J A et al. (1996) Identification of the human P450 enzymes involved in lansoprazole metabolism. J Pharmacol Exp Ther 277:805-16
Mani, C; Pearce, R; Parkinson, A et al. (1994) Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes. Carcinogenesis 15:2715-20
Mani, C; Gelboin, H V; Park, S S et al. (1993) Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. I. Cytochrome P-450-catalyzed N-demethylation and 4-hydroxylation. Drug Metab Dispos 21:645-56
Gemzik, B; Greenway, D; Nevins, C et al. (1992) Regulation of two electrophoretically distinct proteins recognized by antibody against rat liver cytochrome P450 3A1. J Biochem Toxicol 7:43-52
Eberhart, D; Fitzgerald, K; Parkinson, A (1992) Evidence for the involvement of a distinct form of cytochrome P450 3A in the oxidation of digitoxin by rat liver microsomes. J Biochem Toxicol 7:53-64

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