Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM037387-09
Application #
2178760
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1986-02-01
Project End
1996-06-30
Budget Start
1994-04-01
Budget End
1996-06-30
Support Year
9
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Pathology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Zhang, M C; He, L; Giro, M et al. (1999) Cutis laxa arising from frameshift mutations in exon 30 of the elastin gene (ELN). J Biol Chem 274:981-6
Davidson, J M; LuValle, P A; Zoia, O et al. (1997) Ascorbate differentially regulates elastin and collagen biosynthesis in vascular smooth muscle cells and skin fibroblasts by pretranslational mechanisms. J Biol Chem 272:345-52
Quaglino Jr, D; Bergamini, G; Boraldi, F et al. (1996) Connective tissue in skin biopsies from patients suffering systemic sclerosis. J Submicrosc Cytol Pathol 28:287-96
Davidson, J M; Zang, M C; Zoia, O et al. (1995) Regulation of elastin synthesis in pathological states. Ciba Found Symp 192:81-94;discussion 94-9
Zhang, M C; Giro, M; Quaglino Jr, D et al. (1995) Transforming growth factor-beta reverses a posttranscriptional defect in elastin synthesis in a cutis laxa skin fibroblast strain. J Clin Invest 95:986-94
Ruckman, J L; Luvalle, P A; Hill, K E et al. (1994) Phenotypic stability and variation in cells of the porcine aorta: collagen and elastin production. Matrix Biol 14:135-45
Fornieri, C; Quaglino, D; Lungarella, G et al. (1994) Elastin production and degradation in cutis laxa acquisita. J Invest Dermatol 103:583-8
Davidson, J M; Zoia, O; Liu, J M (1993) Modulation of transforming growth factor-beta 1 stimulated elastin and collagen production and proliferation in porcine vascular smooth muscle cells and skin fibroblasts by basic fibroblast growth factor, transforming growth factor-alpha, and insulin-like J Cell Physiol 155:149-56
Gossage, J R; Kuratomi, Y; Davidson, J M et al. (1993) Neutrophil elastase inhibitors, SC-37698 and SC-39026, reduce endotoxin-induced lung dysfunction in awake sheep. Am Rev Respir Dis 147:1371-9
Lane, K B; Zoia, O; Davidson, J M (1992) Semidry electrophoretic transfer of RNA to membranes. Biotechniques 12:340-2, 346

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