Regulation of A 2-Adrenergic Receptors/Adenylate Cyclase

Bylund, David B.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Research Project (R01)
• Project #: 7R01GM037664-03
• Application #: 3293158
• Study Section: Pharmacology A Study Section (PHRA)
• Project Start: 1989-05-01
• Project End: 1990-07-31
• Budget Start: 1989-05-01
• Budget End: 1989-07-31
• Support Year: 3
• Fiscal Year: 1988

Institution

• Name: University of Nebraska Medical Center
• Type: Schools of Pharmacy
• City: Omaha
• State: NE
• Country: United States
• Zip Code: 68198

Publications

Shreve, P E; Toews, M L; Bylund, D B (1991) Alpha 2A- and alpha 2C-adrenoceptor subtypes are differentially down-regulated by norepinephrine. Eur J Pharmacol 207:275-6

Jones, S B; Bylund, D B (1990) Effects of alpha 2-adrenergic agonist preincubation on subsequent forskolin-stimulated adenylate cyclase activity and [3H]forskolin binding in membranes from HT29 cells. Biochem Pharmacol 40:871-7

Jones, S B; Leone, S L; Bylund, D B (1990) Desensitization of the alpha-2 adrenergic receptor in HT29 and opossum kidney cell lines. J Pharmacol Exp Ther 254:294-300

Murphy, T J; Bylund, D B (1989) Characterization of serotonin-1B receptors negatively coupled to adenylate cyclase in OK cells, a renal epithelial cell line from the opossum. J Pharmacol Exp Ther 249:535-43

Jones, S B; Bylund, D B (1988) Characterization and possible mechanisms of alpha 2-adrenergic receptor-mediated sensitization of forskolin-stimulated cyclic AMP production in HT29 cells. J Biol Chem 263:14236-44