Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
7R01GM037674-06
Application #
2444640
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1991-04-01
Project End
1999-06-30
Budget Start
1997-04-01
Budget End
1997-06-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Tufts University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111
Sowadski, J M; Epstein, L F; Lankiewicz, L et al. (1999) Conformational diversity of catalytic cores of protein kinases. Pharmacol Ther 82:157-64
Sowadski, J M; Ellis, C A; Madhusudan (1996) Detergent binding to unmyristylated protein kinase A--structural implications for the role of myristate. J Bioenerg Biomembr 28:7-12
Sowadski, J M (1996) Introduction: crystallization of membrane proteins--in need of a new focus? J Bioenerg Biomembr 28:3-5
Vihinen, M; Vetrie, D; Maniar, H S et al. (1994) Structural basis for chromosome X-linked agammaglobulinemia: a tyrosine kinase disease. Proc Natl Acad Sci U S A 91:12803-7
Madhusudan; Trafny, E A; Xuong, N H et al. (1994) cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer. Protein Sci 3:176-87
Knighton, D R; Cadena, D L; Zheng, J et al. (1993) Structural features that specify tyrosine kinase activity deduced from homology modeling of the epidermal growth factor receptor. Proc Natl Acad Sci U S A 90:5001-5
Zheng, J; Knighton, D R; Xuong, N H et al. (1993) Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations. Protein Sci 2:1559-73
Gibbs, C S; Knighton, D R; Sowadski, J M et al. (1992) Systematic mutational analysis of cAMP-dependent protein kinase identifies unregulated catalytic subunits and defines regions important for the recognition of the regulatory subunit. J Biol Chem 267:4806-14