Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM037687-05
Application #
3293221
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1986-04-01
Project End
1987-09-14
Budget Start
1987-04-01
Budget End
1987-09-14
Support Year
5
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
O'Brien, D P; Oltz, E M; Van Ness, B G (1997) Coordinate transcription and V(D)J recombination of the kappa immunoglobulin light-chain locus: NF-kappaB-dependent and -independent pathways of activation. Mol Cell Biol 17:3477-87
Prabhu, A; O'Brien, D P; Weisner, G L et al. (1996) Octamer independent activation of transcription from the kappa immunoglobulin germline promoter. Nucleic Acids Res 24:4805-11
Schanke, J T; Marcuzzi, A; Podzorski, R P et al. (1994) An AP1 binding site upstream of the kappa immunoglobulin intron enhancer binds inducible factors and contributes to expression. Nucleic Acids Res 22:5425-32
Fulton, R; van Ness, B (1994) Selective synergy of immunoglobulin enhancer elements in B-cell development: a characteristic of kappa light chain enhancers, but not heavy chain enhancers. Nucleic Acids Res 22:4216-23
Schanke, J T; Van Ness, B G (1994) Organization of the transcription factor binding sites in the kappa Ig intron enhancer. Effects of position, orientation, and spacing. J Immunol 153:4565-72
Billadeau, D; Ahmann, G; Greipp, P et al. (1993) The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell. J Exp Med 178:1023-31
Zaknoen, S L; Christian, S L; Suen, R et al. (1992) B-chronic lymphocytic leukemia cells contain both endogenous kappa immunoglobulin mRNA and critical immunoglobulin gene activation transcription factors. Leukemia 6:675-9
Billadeau, D; Quam, L; Thomas, W et al. (1992) Detection and quantitation of malignant cells in the peripheral blood of multiple myeloma patients. Blood 80:1818-24
Billadeau, D; Blackstadt, M; Greipp, P et al. (1991) Analysis of B-lymphoid malignancies using allele-specific polymerase chain reaction: a technique for sequential quantitation of residual disease. Blood 78:3021-9
Nelms, K; Van Ness, B G; Lynch, R G et al. (1991) Enhancer mediated suppression of epsilon heavy-chain gene expression in a murine IgE-producing hybridoma. Mol Immunol 28:599-606

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