Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM037816-04
Application #
3293581
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1987-01-01
Project End
1991-12-31
Budget Start
1990-01-01
Budget End
1990-12-31
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Nilsson, B M; Vargas, H M; Hacksell, U (1992) Amide, urea, and carbamate analogues of the muscarinic agent [4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]trimethylammonium chloride. J Med Chem 35:2787-98
Nilsson, B M; Vargas, H M; Hacksell, U (1992) Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. J Med Chem 35:3270-9
Nilsson, B M; Vargas, H M; Ringdahl, B et al. (1992) Phenyl-substituted analogues of oxotremorine as muscarinic antagonists. J Med Chem 35:285-94
Vargas, H M; Cuevas, J M; Ignarro, L J et al. (1991) Comparison of the inhibitory potencies of N(G)-methyl-, N(G)-nitro- and N(G)-amino-L-arginine on EDRF function in the rat: evidence for continuous basal EDRF release. J Pharmacol Exp Ther 257:1208-15
Vargas, H M; Pechnick, R N (1991) Binding affinity and antimuscarinic activity of sigma and phencyclidine receptor ligands. Eur J Pharmacol 195:151-6
Lundkvist, J R; Vargas, H M; Caldirola, P et al. (1990) Resolved pyrrolidine, piperidine, and perhydroazepine analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. J Med Chem 33:3182-9
Vargas, H M; Ringdahl, B (1990) Centrally active antimuscarinic analogs of oxotremorine selectively block physostigmine-induced hypertension, but not peripheral muscarinic vasodepression. J Pharmacol Exp Ther 253:165-70
Vargas, H M; Ringdahl, B (1990) Antimuscarinic potency and functional selectivity of oxotremorine analogs at muscarinic receptor subtypes in the rat. Life Sci 47:2065-73
Nilsson, B M; Ringdahl, B; Hacksell, U (1990) Beta-lactam analogues of oxotremorine. 3- and 4-methyl-substituted 2-azetidinones. J Med Chem 33:580-4
Vargas, H M; Ignarro, L J; Chaudhuri, G (1990) Physiological release of nitric oxide is dependent on the level of vascular tone. Eur J Pharmacol 190:393-7

Showing the most recent 10 out of 20 publications