Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM039360-09S1
Application #
2420987
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1988-02-01
Project End
1997-03-31
Budget Start
1997-02-01
Budget End
1997-03-31
Support Year
9
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Physiology
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Xia, Jun; Liao, Lan; Sarkar, Joy et al. (2007) Redundant enhancement of mouse constitutive androstane receptor transactivation by p160 coactivator family members. Arch Biochem Biophys 468:49-57
Xia, Jun; Kemper, Byron (2007) Subcellular trafficking signals of constitutive androstane receptor: evidence for a nuclear export signal in the DNA-binding domain. Drug Metab Dispos 35:1489-94
Zhang, Quanyuan; Bae, Yangjin; Kemper, Jongsook Kim et al. (2006) Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2. Arch Biochem Biophys 451:119-27
Xia, Jun; Kemper, Byron (2005) Structural determinants of constitutive androstane receptor required for its glucocorticoid receptor interacting protein-1-mediated nuclear accumulation. J Biol Chem 280:7285-93
Bae, Yangjin; Kemper, Jongsook Kim; Kemper, Byron (2004) Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP). DNA Cell Biol 23:81-91
Rivera-Rivera, Ilia; Kim, Jongsook; Kemper, Byron (2003) Transcriptional analysis in vivo of the hepatic genes, Cyp2b9 and Cyp2b10, by intravenous administration of plasmid DNA in mice. Biochim Biophys Acta 1619:254-62
Min, Gyesik; Kemper, J Kim; Kemper, Byron (2002) Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo. J Biol Chem 277:26356-63
Kim, J; Min, G; Kemper, B (2001) Chromatin assembly enhances binding to the CYP2B1 phenobarbital-responsive unit (PBRU) of nuclear factor-1, which binds simultaneously with constitutive androstane receptor (CAR)/retinoid X receptor (RXR) and enhances CAR/RXR-mediated activation of the PB J Biol Chem 276:7559-67
Liu, S; Rivera-Rivera, I; Bredemeyer, A J et al. (2001) Functional analysis of the phenobarbital-responsive unit in rat CYP2B2. Biochem Pharmacol 62:21-8
Kim, J; Rivera-Rivera, I; Kemper, B (2000) Tissue-specific chromatin structure of the phenobarbital-responsive unit and proximal promoter of CYP2B1/2 and modulation by phenobarbital. Nucleic Acids Res 28:1126-32

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