Abstract

The major goal of this project are to apply the power and versatility of plasma discharge processing and polymer chemistry: (1) to elucidate the mechanism by which certain polyether-coated surfaces are able to resist non-specific protein adsorption or cell adhesion, (2) to develop optimized polyether compositions and practical methodologies for immobilizing such non-fouling compositions on a variety of biomedically important materials used in implants, biosensors, immunoassays, bioprocesses and bioseparations, and (3) to demonstrate the utility of such coatings for an implant (small diameter vascular graft) and a diagnostic test (ELISA immunoassay).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM040111-02
Application #
3297462
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1988-04-01
Project End
1993-03-31
Budget Start
1989-04-01
Budget End
1990-03-31
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Bergstrom, K; Osterberg, E; Holmberg, K et al. (1994) Effects of branching and molecular weight of surface-bound poly(ethylene oxide) on protein rejection. J Biomater Sci Polym Ed 6:123-32
Chen, J P; Kiaei, D; Hoffman, A S (1993) Activity of horseradish peroxide adsorbed on radio frequency glow discharge-treated polymers. J Biomater Sci Polym Ed 5:167-81
Bergstrom, K; Holmberg, K; Safranj, A et al. (1992) Reduction of fibrinogen adsorption on PEG-coated polystyrene surfaces. J Biomed Mater Res 26:779-90