Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM040585-10
Application #
2180454
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1988-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1998-03-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Vermont & St Agric College
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405

  Publications

Xu, B E; Skowronek, K R; Kurjan, J (2001) The N terminus of Saccharomyces cerevisiae Sst2p plays an RGS-domain-independent, Mpt5p-dependent role in recovery from pheromone arrest. Genetics 159:1559-71
DeSimone, S M; Kurjan, J (1998) Switch-domain mutations in the Saccharomyces cerevisiae G protein alpha-subunit Gpa1p identify a receptor subtype-biased mating defect. Mol Gen Genet 257:662-71
Kallal, L; Kurjan, J (1997) Analysis of the receptor binding domain of Gpa1p, the G(alpha) subunit involved in the yeast pheromone response pathway. Mol Cell Biol 17:2897-907
Xu, B E; Kurjan, J (1997) Evidence that mating by the Saccharomyces cerevisiae gpa1Val50 mutant occurs through the default mating pathway and a suggestion of a role for ubiquitin-mediated proteolysis. Mol Biol Cell 8:1649-64
Chen, T; Kurjan, J (1997) Saccharomyces cerevisiae Mpt5p interacts with Sst2p and plays roles in pheromone sensitivity and recovery from pheromone arrest. Mol Cell Biol 17:3429-39
Akada, R; Kallal, L; Johnson, D I et al. (1996) Genetic relationships between the G protein beta gamma complex, Ste5p, Ste20p and Cdc42p: investigation of effector roles in the yeast pheromone response pathway. Genetics 143:103-17
Kurjan, J; Hirsch, J P; Dietzel, C (1991) Mutations in the guanine nucleotide-binding domains of a yeast G alpha protein confer a constitutive or uninducible state to the pheromone response pathway. Genes Dev 5:475-83
Hirsch, J P; Dietzel, C; Kurjan, J (1991) The carboxyl terminus of Scg1, the G alpha subunit involved in yeast mating, is implicated in interactions with the pheromone receptors. Genes Dev 5:467-74
Kang, Y S; Kane, J; Kurjan, J et al. (1990) Effects of expression of mammalian G alpha and hybrid mammalian-yeast G alpha proteins on the yeast pheromone response signal transduction pathway. Mol Cell Biol 10:2582-90