Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM040713-08
Application #
2180545
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1988-07-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Michigan State University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Smith, W L; DeWitt, D L; Garavito, R M (2000) Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 69:145-82
Blanco, J C; Contursi, C; Salkowski, C A et al. (2000) Interferon regulatory factor (IRF)-1 and IRF-2 regulate interferon gamma-dependent cyclooxygenase 2 expression. J Exp Med 191:2131-44
Smith, W L; Meade, E A; Dewitt, D L (1997) Interaction of PGH synthase isozymes-1 and -2 with nonsteroidal anti-inflammatory drugs. Adv Exp Med Biol 400A:189-96
Smith, W L; Garavito, R M; DeWitt, D L (1996) Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem 271:33157-60
Smith, W L; Dewitt, D L (1996) Prostaglandin endoperoxide H synthases-1 and -2. Adv Immunol 62:167-215
Kraemer, S A; Arthur, K A; Denison, M S et al. (1996) Regulation of prostaglandin endoperoxide H synthase-2 expression by 2,3,7,8,-tetrachlorodibenzo-p-dioxin. Arch Biochem Biophys 330:319-28
Breder, C D; Dewitt, D; Kraig, R P (1995) Characterization of inducible cyclooxygenase in rat brain. J Comp Neurol 355:296-315
Laneuville, O; Breuer, D K; Xu, N et al. (1995) Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z, 13E/Z, 15Z)- octadecatrienoic acids from alpha-linolenic acid. J Biol Chem 270:19330-6
Morita, I; Schindler, M; Regier, M K et al. (1995) Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2. J Biol Chem 270:10902-8
Smith, W L; DeWitt, D L (1995) Biochemistry of prostaglandin endoperoxide H synthase-1 and synthase-2 and their differential susceptibility to nonsteroidal anti-inflammatory drugs. Semin Nephrol 15:179-94

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