Imerubrine and grandirubrine are the only known examples of the novel group of tropoloisoquinoline alkaloids. These are the minor alkaloids from several species of Abuta, which are topical vines belonging to the family Menispermaceae. The pharmacological properties of these unusual and rare bases are unknown and neither alkaloid has been synthesized as yet. The goal of this proposal is to synthesize imerubrine and grandirubrine as well as the parent troponoisoquinoline system by using several unrelated synthetic strategies.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM040967-03
Application #
3298926
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1988-12-01
Project End
1992-05-31
Budget Start
1990-12-01
Budget End
1992-05-31
Support Year
3
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Alabama in Tuscaloosa
Department
Type
Schools of Arts and Sciences
DUNS #
City
Tuscaloosa
State
AL
Country
United States
Zip Code
35487