Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM041734-06
Application #
2181019
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1989-12-01
Project End
1997-03-31
Budget Start
1995-07-01
Budget End
1997-03-31
Support Year
6
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Surgery
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Green, Jerril; Doughty, Lesley; Kaplan, Sandra S et al. (2002) The tissue factor and plasminogen activator inhibitor type-1 response in pediatric sepsis-induced multiple organ failure. Thromb Haemost 87:218-23
Kaplan, S S; Simmons, R L (2001) Effect of plasma and matrix proteins on defensin-induced impairment of phagocytic killing by adherent neutrophils. J Biomed Mater Res 57:1-7
Kaplan, S S; Heine, R P; Simmons, R L (1999) Defensins impair phagocytic killing by neutrophils in biomaterial-related infection. Infect Immun 67:1640-5
Doughty, L; Carcillo, J A; Kaplan, S et al. (1998) Plasma nitrite and nitrate concentrations and multiple organ failure in pediatric sepsis. Crit Care Med 26:157-62
Doughty, L; Carcillo, J A; Kaplan, S et al. (1998) The compensatory anti-inflammatory cytokine interleukin 10 response in pediatric sepsis-induced multiple organ failure. Chest 113:1625-31
Kaplan, S S; Lancaster Jr, J R; Basford, R E et al. (1996) Effect of nitric oxide on staphylococcal killing and interactive effect with superoxide. Infect Immun 64:69-76
Kaplan, S S; Basford, R E; Jeong, M H et al. (1996) Biomaterial-neutrophil interactions: dysregulation of oxidative functions of fresh neutrophils induced by prior neutrophil-biomaterial interaction. J Biomed Mater Res 30:67-75
Wong, H R; Carcillo, J A; Burckart, G et al. (1996) Nitric oxide production in critically ill patients. Arch Dis Child 74:482-9
Doughty, L A; Kaplan, S S; Carcillo, J A (1996) Inflammatory cytokine and nitric oxide responses in pediatric sepsis and organ failure. Crit Care Med 24:1137-43
Kaplan, S S (1994) Biomaterial-host interactions: consequences, determined by implant retrieval analysis. Med Prog Technol 20:209-30

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