Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM042896-07
Application #
2181715
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1989-07-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Salazar, M; Fedoroff, O Y; Reid, B R (1996) Structure of chimeric duplex junctions: solution conformation of the retroviral Okazaki-like fragment r(ccca)d(AATGA).d(TCATTTGGG) from Moloney murine leukemia virus. Biochemistry 35:8126-35
Fedoroff OYu; Salazar, M; Reid, B R (1996) Structural variation among retroviral primer-DNA junctions: solution structure of the HIV-1 (-)-strand Okazaki fragment r(gcca)d(CTGC).d(GCAGTGGC). Biochemistry 35:11070-80
Zhu, L; Reid, B R (1995) An improved NOESY simulation program for partially relaxed spectra: BIRDER. J Magn Reson B 106:227-35
Zhu, L; Salazar, M; Reid, B R (1995) DNA duplexes flanked by hybrid duplexes: the solution structure of chimeric junctions in [r(cgcg)d(TATACGCG)]2. Biochemistry 34:2372-80
Wang, A C; Kennedy, M A; Reid, B R et al. (1994) A solid-state 2H NMR investigation of purine motion in a 12 base pair RNA duplex. J Magn Reson B 105:1-10
Salazar, M; Fedoroff OYu; Zhu, L et al. (1994) The solution structure of the r(gcg)d(TATACCC):d(GGGTATACGC) Okazaki fragment contains two distinct duplex morphologies connected by a junction. J Mol Biol 241:440-55
Fedoroff OYu; Salazar, M; Reid, B R (1993) Structure of a DNA:RNA hybrid duplex. Why RNase H does not cleave pure RNA. J Mol Biol 233:509-23
Salazar, M; Champoux, J J; Reid, B R (1993) Sugar conformations at hybrid duplex junctions in HIV-1 and Okazaki fragments. Biochemistry 32:739-44
Salazar, M; Fedoroff, O Y; Miller, J M et al. (1993) The DNA strand in DNA.RNA hybrid duplexes is neither B-form nor A-form in solution. Biochemistry 32:4207-15
Wang, A C; Kim, S G; Flynn, P F et al. (1992) Errors in RNA NOESY distance measurements in chimeric and hybrid duplexes: differences in RNA and DNA proton relaxation. Biochemistry 31:3940-6

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