Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM043049-11
Application #
2181774
Study Section
Molecular Cytology Study Section (CTY)
Project Start
1985-09-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cold Spring Harbor Laboratory
Department
Type
DUNS #
065968786
City
Cold Spring Harbor
State
NY
Country
United States
Zip Code
11724
Chen, C D; Kobayashi, R; Helfman, D M (1999) Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta-tropomyosin gene. Genes Dev 13:593-606
Selvakumar, M; Helfman, D M (1999) Exonic splicing enhancers contribute to the use of both 3' and 5' splice site usage of rat beta-tropomyosin pre-mRNA. RNA 5:378-94
Lou, H; Helfman, D M; Gagel, R F et al. (1999) Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3'-terminal exon. Mol Cell Biol 19:78-85
Chen, C D; Helfman, D M (1999) Donor site competition is involved in the regulation of alternative splicing of the rat beta-tropomyosin pre-mRNA. RNA 5:290-301
Grossman, J S; Meyer, M I; Wang, Y C et al. (1998) The use of antibodies to the polypyrimidine tract binding protein (PTB) to analyze the protein components that assemble on alternatively spliced pre-mRNAs that use distant branch points. RNA 4:613-25
Helfman, D M (1994) The generation of protein isoform diversity by alternative RNA splicing. Soc Gen Physiol Ser 49:105-15
Pittenger, M F; Kazzaz, J A; Helfman, D M (1994) Functional properties of non-muscle tropomyosin isoforms. Curr Opin Cell Biol 6:96-104
Tsukahara, T; Casciato, C; Helfman, D M (1994) Alternative splicing of beta-tropomyosin pre-mRNA: multiple cis-elements can contribute to the use of the 5'- and 3'-splice sites of the nonmuscle/smooth muscle exon 6. Nucleic Acids Res 22:2318-25
Stamm, S; Zhang, M Q; Marr, T G et al. (1994) A sequence compilation and comparison of exons that are alternatively spliced in neurons. Nucleic Acids Res 22:1515-26
Stamm, S; Mulligan, G J; Krainer, A R et al. (1994) Non-radioactive detection of m3G capped RNAs by immunoblotting. Nucleic Acids Res 22:252-3

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