Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM043154-08
Application #
2181835
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1989-12-01
Project End
1999-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Pharmacology
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Callender, Julia A; Yang, Yimin; Lordén, Gema et al. (2018) Protein kinase C? gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation. Proc Natl Acad Sci U S A 115:E5497-E5505
Balasuriya, Nileeka; Kunkel, Maya T; Liu, Xuguang et al. (2018) Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity. J Biol Chem 293:10744-10756
Newton, Alexandra C (2018) Protein kinase C as a tumor suppressor. Semin Cancer Biol 48:18-26
Newton, Alexandra C; Brognard, John (2017) Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor. Trends Pharmacol Sci 38:438-447
Newton, Alexandra C; Antal, Corina E; Steinberg, Susan F (2016) Protein kinase C mechanisms that contribute to cardiac remodelling. Clin Sci (Lond) 130:1499-510
Tobias, Irene S; Kaulich, Manuel; Kim, Peter K et al. (2016) Protein kinase C? exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation. Biochem J 473:509-23
Hollands, Andrew; Corriden, Ross; Gysler, Gabriela et al. (2016) Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. J Biol Chem 291:13964-73
Newton, Alexandra C; Tanzi, Rudolph E; VanHook, Annalisa M (2016) Science Signaling Podcast for 10 May 2016: PKC? in Alzheimer's disease. Sci Signal 9:pc11
McSkimming, Daniel Ian; Dastgheib, Shima; Baffi, Timothy R et al. (2016) KinView: a visual comparative sequence analysis tool for integrated kinome research. Mol Biosyst 12:3651-3665
Alfonso, Stephanie I; Callender, Julia A; Hooli, Basavaraj et al. (2016) Gain-of-function mutations in protein kinase C? (PKC?) may promote synaptic defects in Alzheimer's disease. Sci Signal 9:ra47

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