Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM043189-02
Application #
3302168
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1991-01-01
Project End
1995-12-31
Budget Start
1992-01-01
Budget End
1992-12-31
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Earley, K; Luo, W; Qiu, Y et al. (1996) Identification of a new isoform of cell-cell adhesion molecule 105 (C-CAM), C-CAM4: a secretory protein with only one Ig domain. Biochem J 315 ( Pt 3):799-806
Luo, W; Liang, T C; Li, J M et al. (1996) A universal tag for recombinant proteins. Arch Biochem Biophys 329:215-20
Liang, T C; Luo, W; Hsieh, J T et al. (1996) Antibody binding to a peptide but not the whole protein by recognition of the C-terminal carboxy group. Arch Biochem Biophys 329:208-14
Kleinerman, D I; Dinney, C P; Zhang, W W et al. (1996) Suppression of human bladder cancer growth by increased expression of C-CAM1 gene in an orthotopic model. Cancer Res 56:3431-5
Kleinerman, D I; Zhang, W W; Lin, S H et al. (1995) Application of a tumor suppressor (C-CAM1)-expressing recombinant adenovirus in androgen-independent human prostate cancer therapy: a preclinical study. Cancer Res 55:2831-6
Kleinerman, D I; Troncoso, P; Lin, S H et al. (1995) Consistent expression of an epithelial cell adhesion molecule (C-CAM) during human prostate development and loss of expression in prostate cancer: implication as a tumor suppressor. Cancer Res 55:1215-20
Lin, S H; Luo, W; Earley, K et al. (1995) Structure and function of C-CAM1: effects of the cytoplasmic domain on cell aggregation. Biochem J 311 ( Pt 1):239-45
Hsieh, J T; Luo, W; Song, W et al. (1995) Tumor suppressive role of an androgen-regulated epithelial cell adhesion molecule (C-CAM) in prostate carcinoma cell revealed by sense and antisense approaches. Cancer Res 55:190-7
Hsieh, J T; Lin, S H (1994) Androgen regulation of cell adhesion molecule gene expression in rat prostate during organ degeneration. C-CAM belongs to a class of androgen-repressed genes associated with enriched stem/amplifying cell population after prolonged castration. J Biol Chem 269:3711-6
Thompson, N L; Lin, S H; Panzica, M A et al. (1994) Cell CAM 105 isoform RNA expression is differentially regulated during rat liver regeneration and carcinogenesis. Pathobiology 62:209-20

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