Abstract

Development of guidelines for the design of pH-sensitive, swelling- controlled release systems for delivery of drugs, bimolecules and genetically-engineered molecules is investigated. The novel systems are produced from hydrophilic, ionic, glassy polymers which can swell in water or biological fluids. Mechanisms of water-soluble solute diffusion through initially glassy, continuously swelling hydrophilic polymer systems are investigated. Experimental studies are performed with crosslinked copolymers of 2-hydroxyethyl methacrylate with methacrylic acid, N-vinyl- pyrrolidone and various acrylamides using several solutes of low or high molecular weight. The effect of degree of crosslinking and dynamic swelling behavior of the polymer on solute diffusion are studied with a combination of diffusion/dissolution/microtoming/microscopy/stress relaxation experiments. The mesh size is determined experimentally by equilibrium swelling studies. Models are developed for the pH sensitivity of the degree of swelling and the dynamic swelling of these hydrogels.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM043337-03
Application #
3302401
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1989-12-01
Project End
1993-05-31
Budget Start
1991-12-01
Budget End
1993-05-31
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Purdue University
Department
Type
Schools of Engineering
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907

  Publications

Sainz, Vanessa; Moura, Liane I F; Peres, Carina et al. (2018) ?-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effect in melanoma. Acta Biomater 76:193-207
Bae, Hojae; Puranik, Amey S; Gauvin, Robert et al. (2012) Building vascular networks. Sci Transl Med 4:160ps23
Liechty, William B; Caldorera-Moore, Mary; Phillips, Margaret A et al. (2011) Advanced molecular design of biopolymers for transmucosal and intracellular delivery of chemotherapeutic agents and biological therapeutics. J Control Release 155:119-27
Foss, Aaron C; Goto, Takahiro; Morishita, Mariko et al. (2004) Development of acrylic-based copolymers for oral insulin delivery. Eur J Pharm Biopharm 57:163-9
Torres-Lugo, Madeline; Garcia, Marcos; Record, Rae et al. (2002) pH-Sensitive hydrogels as gastrointestinal tract absorption enhancers: transport mechanisms of salmon calcitonin and other model molecules using the Caco-2 cell model. Biotechnol Prog 18:612-6
Baumgartner, Saia; Kristl, Julijana; Peppas, Nicholas A (2002) Network structure of cellulose ethers used in pharmaceutical applications during swelling and at equilibrium. Pharm Res 19:1084-90
Torres-Lugo, Madeline; Garcia, Marcos; Record, Rae et al. (2002) Physicochemical behavior and cytotoxic effects of p(methacrylic acid-g-ethylene glycol) nanospheres for oral delivery of proteins. J Control Release 80:197-205
Zhang, J; Peppas, N A (2002) Morphology of poly(methacrylic acid)/poly(N-isopropyl acrylamide) interpenetrating polymeric networks. J Biomater Sci Polym Ed 13:511-25
Peppas, Nicholas A; Huang, Yanbin (2002) Polymers and gels as molecular recognition agents. Pharm Res 19:578-87
Bures, P; Huang, Y; Oral, E et al. (2001) Surface modifications and molecular imprinting of polymers in medical and pharmaceutical applications. J Control Release 72:25-33

Showing the most recent 10 out of 21 publications