Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM043753-07
Application #
2182159
Study Section
Endocrinology Study Section (END)
Project Start
1990-04-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Genetics
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Russell, D W; Berman, D M; Bryant, J T et al. (1994) The molecular genetics of steroid 5 alpha-reductases. Recent Prog Horm Res 49:275-84
Wigley, W C; Prihoda, J S; Mowszowicz, I et al. (1994) Natural mutagenesis study of the human steroid 5 alpha-reductase 2 isozyme. Biochemistry 33:1265-70
Russell, D W; Wilson, J D (1994) Steroid 5 alpha-reductase: two genes/two enzymes. Annu Rev Biochem 63:25-61
Thigpen, A E; Silver, R I; Guileyardo, J M et al. (1993) Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression. J Clin Invest 92:903-10
Berman, D M; Russell, D W (1993) Cell-type-specific expression of rat steroid 5 alpha-reductase isozymes. Proc Natl Acad Sci U S A 90:9359-63
Thigpen, A E; Cala, K M; Russell, D W (1993) Characterization of Chinese hamster ovary cell lines expressing human steroid 5 alpha-reductase isozymes. J Biol Chem 268:17404-12
Davis, D L; Russell, D W (1993) Unusual length polymorphism in human steroid 5 alpha-reductase type 2 gene (SRD5A2). Hum Mol Genet 2:820
Hirsch, K S; Jones, C D; Audia, J E et al. (1993) LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1. Proc Natl Acad Sci U S A 90:5277-81
Wilson, J D; Griffin, J E; Russell, D W (1993) Steroid 5 alpha-reductase 2 deficiency. Endocr Rev 14:577-93
Normington, K; Russell, D W (1992) Tissue distribution and kinetic characteristics of rat steroid 5 alpha-reductase isozymes. Evidence for distinct physiological functions. J Biol Chem 267:19548-54

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