Ligand Reactivity in Heme Proteins

Friedman, Joel M.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Research Project (R01)
• Project #: 5R01GM044343-04
• Application #: 2182483
• Study Section: Molecular and Cellular Biophysics Study Section (BBCA)
• Project Start: 1992-09-30
• Project End: 1997-08-31
• Budget Start: 1995-09-01
• Budget End: 1997-08-31
• Support Year: 4
• Fiscal Year: 1995

Institution

• Name: Albert Einstein College of Medicine
• Department: Physiology
• Type: Schools of Medicine
• DUNS #: 009095365
• City: Bronx
• State: NY
• Country: United States
• Zip Code: 10461

Publications

Falconi, M; Desideri, A; Cupane, A et al. (1998) Structural and dynamic properties of the homodimeric hemoglobin from Scapharca inaequivalvis Thr-72-->Ile mutant: molecular dynamics simulation, low temperature visible absorption spectroscopy, and resonance Raman spectroscopy studies. Biophys J 75:2489-503

Peterson, E S; Friedman, J M; Chien, E Y et al. (1998) Functional implications of the proximal hydrogen-bonding network in myoglobin: a resonance Raman and kinetic study of Leu89, Ser92, His97, and F-helix swap mutants. Biochemistry 37:12301-19

Peterson, E S; Huang, S; Wang, J et al. (1997) A comparison of functional and structural consequences of the tyrosine B10 and glutamine E7 motifs in two invertebrate hemoglobins (Ascaris suum and Lucina pectinata). Biochemistry 36:13110-21

Huang, S; Peterson, E S; Ho, C et al. (1997) Quaternary structure sensitive tyrosine interactions in hemoglobin: a UV resonance Raman study of the double mutant rHb (beta99Asp-->Asn, alpha42Tyr-->Asp). Biochemistry 36:6197-206

Huang, S; Huang, J; Kloek, A P et al. (1996) Hydrogen bonding of tyrosine B10 to heme-bound oxygen in Ascaris hemoglobin. Direct evidence from UV resonance Raman spectroscopy. J Biol Chem 271:958-62