Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM045011-06
Application #
2182924
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1990-06-05
Project End
1997-06-30
Budget Start
1995-12-01
Budget End
1997-06-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wistar Institute
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Cudic, M; Otvos Jr, L (2002) Intracellular targets of antibacterial peptides. Curr Drug Targets 3:101-6
Vlad, Anda M; Muller, Stefan; Cudic, Mare et al. (2002) Complex carbohydrates are not removed during processing of glycoproteins by dendritic cells: processing of tumor antigen MUC1 glycopeptides for presentation to major histocompatibility complex class II-restricted T cells. J Exp Med 196:1435-46
Cudic, Mare; Ertl, Hildegund C J; Otvos Jr, Laszlo (2002) Synthesis, conformation and T-helper cell stimulation of an O-linked glycopeptide epitope containing extended carbohydrate side-chains. Bioorg Med Chem 10:3859-70
Kragol, G; Otvos Jr, L; Feng, J et al. (2001) Synthesis of a disulfide-linked octameric peptide construct carrying three different antigenic determinants. Bioorg Med Chem Lett 11:1417-20
Kragol, G; Lovas, S; Varadi, G et al. (2001) The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding. Biochemistry 40:3016-26
Otvos Jr, L (2000) Antibacterial peptides isolated from insects. J Pept Sci 6:497-511
Otvos Jr, L; Pease, A M; Bokonyi, K et al. (2000) In situ stimulation of a T helper cell hybridoma with a cellulose-bound peptide antigen. J Immunol Methods 233:95-105
Otvos Jr, L; O, I; Rogers, M E et al. (2000) Interaction between heat shock proteins and antimicrobial peptides. Biochemistry 39:14150-9
Otvos Jr, L; Bokonyi, K; Varga, I et al. (2000) Insect peptides with improved protease-resistance protect mice against bacterial infection. Protein Sci 9:742-9
Cudic, M; Bulet, P; Hoffmann, R et al. (1999) Chemical synthesis, antibacterial activity and conformation of diptericin, an 82-mer peptide originally isolated from insects. Eur J Biochem 266:549-58

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