Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM046526-05A1
Application #
2184032
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1991-08-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
Lobb, R R; Hemler, M E (1994) The pathophysiologic role of alpha 4 integrins in vivo. J Clin Invest 94:1722-8
Kawaguchi, S; Bergelson, J M; Finberg, R W et al. (1994) Integrin alpha 2 cytoplasmic domain deletion effects: loss of adhesive activity parallels ligand-independent recruitment into focal adhesions. Mol Biol Cell 5:977-88
Kassner, P D; Kawaguchi, S; Hemler, M E (1994) Minimum alpha chain cytoplasmic tail sequence needed to support integrin-mediated adhesion. J Biol Chem 269:19859-67
Masumoto, A; Hemler, M E (1993) Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1. J Biol Chem 268:228-34
Masumoto, A; Hemler, M E (1993) Mutation of putative divalent cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin. J Cell Biol 123:245-53
Chan, B M; Hemler, M E (1993) Multiple functional forms of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion of forms induced by an anti-beta 1 antibody. J Cell Biol 120:537-43
Weitzman, J B; Pasqualini, R; Takada, Y et al. (1993) The function and distinctive regulation of the integrin VLA-3 in cell adhesion, spreading, and homotypic cell aggregation. J Biol Chem 268:8651-7
Kawaguchi, S; Hemler, M E (1993) Role of the alpha subunit cytoplasmic domain in regulation of adhesive activity mediated by the integrin VLA-2. J Biol Chem 268:16279-85
Kassner, P D; Hemler, M E (1993) Interchangeable alpha chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a beta 1 integrin. J Exp Med 178:649-60
Chan, B M; Kassner, P D; Schiro, J A et al. (1992) Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains. Cell 68:1051-60

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