Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM046764-04
Application #
2184252
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1992-02-01
Project End
1997-01-31
Budget Start
1995-02-01
Budget End
1997-01-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Asano, Y; Koehler, R C; Kawaguchi, T et al. (1997) Pial arteriolar constriction to alpha 2-adrenergic agonist dexmedetomidine in the rat. Am J Physiol 272:H2547-56
McPherson, R W; Koehler, R C; Kirsch, J R et al. (1997) Intraventricular dexmedetomidine decreases cerebral blood flow during normoxia and hypoxia in dogs. Anesth Analg 84:139-47
McPherson, R W; Kirsch, J R; Ghaly, R F et al. (1995) Effect of nitric oxide synthase inhibition on the cerebral vascular response to hypercapnia in primates. Stroke 26:682-7
McPherson, R W; Kirsch, J R; Tobin, J R et al. (1994) Cerebral blood flow in primates is increased by isoflurane over time and is decreased by nitric oxide synthase inhibition. Anesthesiology 80:1320-7
Sturaitis, M K; Moore, L E; Kirsch, J R et al. (1994) A cholinergic agonist induces cerebral hyperemia in isoflurane- but not pentobarbital-anesthetized dogs. Anesth Analg 78:876-83
McPherson, R W; Koehler, R C; Traystman, R J (1994) Hypoxia, alpha 2-adrenergic, and nitric oxide-dependent interactions on canine cerebral blood flow. Am J Physiol 266:H476-82
Fale, A; Kirsch, J R; McPherson, R W (1994) Alpha 2-adrenergic agonist effects on normocapnic and hypercapnic cerebral blood flow in the dog are anesthetic dependent. Anesth Analg 79:892-8
McPherson, R W; Kirsch, J R; Traystman, R J (1994) Inhibition of nitric oxide synthase does not affect alpha 2-adrenergic-mediated cerebral vasoconstriction. Anesth Analg 78:67-72
McPherson, R W; Kirsch, J R; Moore, L E et al. (1993) N omega-nitro-L-arginine methyl ester prevents cerebral hyperemia by inhaled anesthetics in dogs. Anesth Analg 77:891-7