Abstract

Dr. Quaranta's major interest is structure and function of adhesion receptor integrins in epithelial cells. His studies have focussed on the integrin alpha6beta4, which is epithelial-specific and most likely plays a crucial role in regulating interactions of many epithelia with basement membranes. Studies will be directed at uncovering the physical nature and molecular basis of alpha6beta4 functions.
Specific aims are: (1) to identify the ligand(s) for the integrin alpha6beta4 and carry out its molecular characterization, including cDNA cloning; (2) to investigate the functional significance of the interaction of alpha6beta4 with its ligand(s); (3) to investigate the functions of the alternative cytoplasmic domains of alpha6 and of the large cytoplasmic domain of beta4.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM046902-03
Application #
2184392
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1992-02-01
Project End
1996-01-31
Budget Start
1994-02-01
Budget End
1995-01-31
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Hintermann, Edith; Yang, Neng; O'Sullivan, Deirdre et al. (2005) Integrin alpha6beta4-erbB2 complex inhibits haptotaxis by up-regulating E-cadherin cell-cell junctions in keratinocytes. J Biol Chem 280:8004-15
Koshikawa, Naohiko; Minegishi, Tomoko; Sharabi, Andrew et al. (2005) Membrane-type matrix metalloproteinase-1 (MT1-MMP) is a processing enzyme for human laminin gamma 2 chain. J Biol Chem 280:88-93
Bilban, Martin; Ghaffari-Tabrizi, Nassim; Hintermann, Edith et al. (2004) Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts. J Cell Sci 117:1319-28
Hendrix, Mary J C; Seftor, Elisabeth A; Kirschmann, Dawn A et al. (2003) Remodeling of the microenvironment by aggressive melanoma tumor cells. Ann N Y Acad Sci 995:151-61
Schenk, Susann; Hintermann, Edith; Bilban, Martin et al. (2003) Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution. J Cell Biol 161:197-209
Bilban, Martin; Buehler, Lukas K; Head, Steven et al. (2002) Normalizing DNA microarray data. Curr Issues Mol Biol 4:57-64
Hintermann, Edith; Haake, Susan Kinder; Christen, Urs et al. (2002) Discrete proteolysis of focal contact and adherens junction components in Porphyromonas gingivalis-infected oral keratinocytes: a strategy for cell adhesion and migration disabling. Infect Immun 70:5846-56
Seftor, R E; Seftor, E A; Koshikawa, N et al. (2001) Cooperative interactions of laminin 5 gamma2 chain, matrix metalloproteinase-2, and membrane type-1-matrix/metalloproteinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma. Cancer Res 61:6322-7
Hintermann, E; Bilban, M; Sharabi, A et al. (2001) Inhibitory role of alpha 6 beta 4-associated erbB-2 and phosphoinositide 3-kinase in keratinocyte haptotactic migration dependent on alpha 3 beta 1 integrin. J Cell Biol 153:465-78
Kiosses, W B; Hahn, K M; Giannelli, G et al. (2001) Characterization of morphological and cytoskeletal changes in MCF10A breast epithelial cells plated on laminin-5: comparison with breast cancer cell line MCF7. Cell Commun Adhes 8:29-44

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