Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM046904-05
Application #
2184401
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1992-02-01
Project End
1997-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Chicago
Department
Biochemistry
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Hickey, Christopher M; Xie, Yang; Hochstrasser, Mark (2018) DNA binding by the MAT?2 transcription factor controls its access to alternative ubiquitin-modification pathways. Mol Biol Cell 29:542-556
Budenholzer, Lauren; Cheng, Chin Leng; Li, Yanjie et al. (2017) Proteasome Structure and Assembly. J Mol Biol 429:3500-3524
Huber, Eva M; Heinemeyer, Wolfgang; Li, Xia et al. (2016) A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome. Nat Commun 7:10900
Ronau, Judith A; Beckmann, John F; Hochstrasser, Mark (2016) Substrate specificity of the ubiquitin and Ubl proteases. Cell Res 26:441-56
Zattas, Dimitrios; Berk, Jason M; Kreft, Stefan G et al. (2016) A Conserved C-terminal Element in the Yeast Doa10 and Human MARCH6 Ubiquitin Ligases Required for Selective Substrate Degradation. J Biol Chem 291:12105-18
Li, Xia; Li, Yanjie; Arendt, Cassandra S et al. (2016) Distinct Elements in the Proteasomal ?5 Subunit Propeptide Required for Autocatalytic Processing and Proteasome Assembly. J Biol Chem 291:1991-2003
Padmanabhan, Achuth; Vuong, Simone Anh-Thu; Hochstrasser, Mark (2016) Assembly of an Evolutionarily Conserved Alternative Proteasome Isoform in Human Cells. Cell Rep 14:2962-74
Zattas, Dimitrios; Hochstrasser, Mark (2015) Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope. Crit Rev Biochem Mol Biol 50:1-17
Hickey, Christopher M; Hochstrasser, Mark (2015) STUbL-mediated degradation of the transcription factor MAT?2 requires degradation elements that coincide with corepressor binding sites. Mol Biol Cell 26:3401-12
Kunjappu, Mary J; Hochstrasser, Mark (2014) Assembly of the 20S proteasome. Biochim Biophys Acta 1843:2-12

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