Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM047012-04
Application #
2184484
Study Section
Special Emphasis Panel (ZRG3-BBCA (01))
Project Start
1993-08-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Mount Sinai School of Medicine
Department
Biostatistics & Other Math Sci
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Mielke, Christian; Christensen, Morten O; Westergaard, Ole et al. (2002) Multiple collagen I gene regulatory elements have sites of stress-induced DNA duplex destabilization and nuclear scaffold/matrix association potential. J Cell Biochem 84:484-96
Benham, Craig J; Savitt, Anne G; Bauer, William R (2002) Extrusion of an imperfect palindrome to a cruciform in superhelical DNA: complete determination of energetics using a statistical mechanical model. J Mol Biol 316:563-81
Mistry, S J; Benham, C J; Atweh, G F (2001) Development of ribozymes that target stathmin, a major regulator of the mitotic spindle. Antisense Nucleic Acid Drug Dev 11:41-9
Moore, P B; Lopez, C F; Klein, M L (2001) Dynamical properties of a hydrated lipid bilayer from a multinanosecond molecular dynamics simulation. Biophys J 81:2484-94
Benham, C J (2001) Stress-induced DNA duplex destabilization in transcriptional initiation. Pac Symp Biocomput :103-14
Baiker, A; Maercker, C; Piechaczek, C et al. (2000) Mitotic stability of an episomal vector containing a human scaffold/matrix-attached region is provided by association with nuclear matrix. Nat Cell Biol 2:182-4
Leblanc, B P; Benham, C J; Clark, D J (2000) An initiation element in the yeast CUP1 promoter is recognized by RNA polymerase II in the absence of TATA box-binding protein if the DNA is negatively supercoiled. Proc Natl Acad Sci U S A 97:10745-50
Sheridan, S D; Benham, C J; Hatfield, G W (1999) Inhibition of DNA supercoiling-dependent transcriptional activation by a distant B-DNA to Z-DNA transition. J Biol Chem 274:8169-74
Sheridan, S D; Benham, C J; Hatfield, G W (1998) Activation of gene expression by a novel DNA structural transmission mechanism that requires supercoiling-induced DNA duplex destabilization in an upstream activating sequence. J Biol Chem 273:21298-308
Benham, C J (1996) Duplex destabilization in superhelical DNA is predicted to occur at specific transcriptional regulatory regions. J Mol Biol 255:425-34

Showing the most recent 10 out of 12 publications