Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM047124-05A1
Application #
2184538
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1991-04-01
Project End
1999-11-30
Budget Start
1995-12-15
Budget End
1996-11-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Pharmacology
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Adedoyin, A; Swenson, C E; Bolcsak, L E et al. (2000) A pharmacokinetic study of amphotericin B lipid complex injection (Abelcet) in patients with definite or probable systemic fungal infections. Antimicrob Agents Chemother 44:2900-2
Dubey, R K; Tyurina, Y Y; Tyurin, V A et al. (1999) Estrogen and tamoxifen metabolites protect smooth muscle cell membrane phospholipids against peroxidation and inhibit cell growth. Circ Res 84:229-39
Osaka, K; Tyurina, Y Y; Dubey, R K et al. (1997) Amphotericin B as an intracellular antioxidant: protection against 2,2'-azobis(2,4-dimethylvaleronitrile)-induced peroxidation of membrane phospholipids in rat aortic smooth muscle cells. Biochem Pharmacol 54:937-45
Dubey, R K; Jackson, E K; Rupprecht, H D et al. (1997) Factors controlling growth and matrix production in vascular smooth muscle and glomerular mesangial cells. Curr Opin Nephrol Hypertens 6:88-105
Adedoyin, A; Bernardo, J F; Swenson, C E et al. (1997) Pharmacokinetic profile of ABELCET (amphotericin B lipid complex injection): combined experience from phase I and phase II studies. Antimicrob Agents Chemother 41:2201-8
Osaka, K; Ritov, V B; Bernardo, J F et al. (1997) Amphotericin B protects cis-parinaric acid against peroxyl radical-induced oxidation: amphotericin B as an antioxidant. Antimicrob Agents Chemother 41:743-7
Murakami, S; Ohno, T; Bernardo, J F et al. (1996) Reduced liver function is the trigger for renal sodium retention following portal vein ligation in the rat. J Gastroenterol Hepatol 11:850-6
Murakami, S; Bernardo, J F; Branch, R A et al. (1996) Adenosine does not mediate renal sodium retention and peripheral vasodilation elicited by partial portal vein ligation in rats. Hepatology 23:346-52
Bernardo, J F; Murakami, S; Branch, R A et al. (1995) Potassium depletion potentiates amphotericin-B-induced toxicity to renal tubules. Nephron 70:235-41
Murakami, S; Bernardo, J F; Jacob, T D et al. (1995) Nitric oxide does not contribute to sodium retention and peripheral vasodilation induced by partial portal vein ligation in rats. Ren Physiol Biochem 18:198-208