Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM047535-04
Application #
2185010
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1993-01-01
Project End
1996-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Florida
Department
Pharmacology
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Schneider-Berlin, Kristen R; Bonilla, Tonya D; Rowe, Thomas C (2005) Induction of petite mutants in yeast Saccharomyces cerevisiae by the anticancer drug dequalinium. Mutat Res 572:84-97
Rowe, T C; Grabowski, D; Ganapathi, R (2001) Isolation of covalent enzyme-DNA complexes. Methods Mol Biol 95:129-35
Rowe, T C; Weissig, V; Lawrence, J W (2001) Mitochondrial DNA metabolism targeting drugs. Adv Drug Deliv Rev 49:175-87
Weissig, V; Rowe, T C (1999) Analysis of Plasmodium falciparum mitochondrial six-kilobase DNA by pulse-field electrophoresis. J Parasitol 85:386-9
Schneider Berlin, K R; Ammini, C V; Rowe, T C (1998) Dequalinium induces a selective depletion of mitochondrial DNA from HeLa human cervical carcinoma cells. Exp Cell Res 245:137-45
Weissig, V; Lasch, J; Erdos, G et al. (1998) DQAsomes: a novel potential drug and gene delivery system made from Dequalinium. Pharm Res 15:334-7
Weissig, V; Vetro-Widenhouse, T S; Rowe, T C (1997) Topoisomerase II inhibitors induce cleavage of nuclear and 35-kb plastid DNAs in the malarial parasite Plasmodium falciparum. DNA Cell Biol 16:1483-92
Lawrence, J W; Claire, D C; Weissig, V et al. (1996) Delayed cytotoxicity and cleavage of mitochondrial DNA in ciprofloxacin-treated mammalian cells. Mol Pharmacol 50:1178-88