Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
7R01GM048131-03
Application #
3307593
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1992-08-05
Project End
1995-07-31
Budget Start
1994-06-01
Budget End
1994-07-31
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Type
Schools of Medicine
DUNS #
605799469
City
Newark
State
NJ
Country
United States
Zip Code
07107
Swank, G M; Lu, Q; Xu, D Z et al. (1998) Effect of acute-phase and heat-shock stress on apoptosis in intestinal epithelial cells (Caco-2). Crit Care Med 26:1213-7
Xu, D; Lu, Q; Deitch, E A (1998) Elemental diet-induced bacterial translocation associated with systemic and intestinal immune suppression. JPEN J Parenter Enteral Nutr 22:37-41
Michalsky, M P; Deitch, E A; Ding, J et al. (1997) Interleukin-6 and tumor necrosis factor production in an enterocyte cell model (Caco-2) during exposure to Escherichia coli. Shock 7:139-46
Katayama, M; Xu, D; Specian, R D et al. (1997) Role of bacterial adherence and the mucus barrier on bacterial translocation: effects of protein malnutrition and endotoxin in rats. Ann Surg 225:317-26
Xu, D Z; Lu, Q; Swank, G M et al. (1996) Effect of heat shock and endotoxin stress on enterocyte viability apoptosis and function varies based on whether the cells are exposed to heat shock or endotoxin first. Arch Surg 131:1222-8
Deitch, E A (1995) Nutritional support of the burn patient. Crit Care Clin 11:735-50
Deitch, E A; Xu, D; Naruhn, M B et al. (1995) Elemental diet and IV-TPN-induced bacterial translocation is associated with loss of intestinal mucosal barrier function against bacteria. Ann Surg 221:299-307
Deitch, E A; Beck, S C; Cruz, N C et al. (1995) Induction of heat shock gene expression in colonic epithelial cells after incubation with Escherichia coli or endotoxin. Crit Care Med 23:1371-6
Deitch, E A; Haskel, Y; Cruz, N et al. (1995) Caco-2 and IEC-18 intestinal epithelial cells exert bactericidal activity through an oxidant-dependent pathway. Shock 4:345-50
Haskel, Y; Xu, D; Lu, Q et al. (1994) Bombesin protects against bacterial translocation induced by three commercially available liquid enteral diets: a prospective, randomized, multigroup trial. Crit Care Med 22:108-13

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