Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM048224-09
Application #
2185715
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1993-07-01
Project End
1997-03-31
Budget Start
1995-07-01
Budget End
1997-03-31
Support Year
9
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Miami School of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146
Davis, Joseph H; Baker, Tania A; Sauer, Robert T (2009) Engineering synthetic adaptors and substrates for controlled ClpXP degradation. J Biol Chem 284:21848-55
McGinness, Kathleen E; Bolon, Daniel N; Kaganovich, Mark et al. (2007) Altered tethering of the SspB adaptor to the ClpXP protease causes changes in substrate delivery. J Biol Chem 282:11465-73
Bottazzi, M E; Buzzai, M; Zhu, X et al. (2001) Distinct effects of mitogens and the actin cytoskeleton on CREB and pocket protein phosphorylation control the extent and timing of cyclin A promoter activity. Mol Cell Biol 21:7607-16
Zhu, X; Scharf, E; Assoian, R K (2000) Induction of anchorage-independent growth by transforming growth factor-beta linked to anchorage-independent expression of cyclin D1. J Biol Chem 275:6703-6
Davey, G; Buzzai, M; Assoian, R K (1999) Reduced expression of (alpha)5(beta)1 integrin prevents spreading-dependent cell proliferation. J Cell Sci 112 ( Pt 24):4663-72
Dalton, S L; Scharf, E; Davey, G et al. (1999) Transforming growth factor-beta overrides the adhesion requirement for surface expression of alpha(5)beta(1) integrin in normal rat kidney fibroblasts. A necessary effect for induction of anchorage-independent growth. J Biol Chem 274:30139-45
Bohmer, R M; Scharf, E; Assoian, R K (1996) Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1. Mol Biol Cell 7:101-111
Zhu, X; Assoian, R K (1995) Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation. Mol Biol Cell 6:273-82
Wager, R E; Scotto, L; Assoian, R K (1994) Analysis of transforming growth factor beta 1 messenger RNA degradation by the transcript-selective, 12-O-tetradecanoylphorbol-13-acetate-regulated ribonuclease system from U937 promonocytes. Cell Growth Differ 5:117-24
Han, E K; Guadagno, T M; Dalton, S L et al. (1993) A cell cycle and mutational analysis of anchorage-independent growth: cell adhesion and TGF-beta 1 control G1/S transit specifically. J Cell Biol 122:461-71

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