Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM048749-04
Application #
2186287
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1993-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1998-06-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Michael, S L; Pumford, N R; Mayeux, P R et al. (1999) Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species. Hepatology 30:186-95
Matthews, A M; Hinson, J A; Roberts, D W et al. (1997) Comparison of covalent binding of acetaminophen and the regioisomer 3'-hydroxyacetanilide to mouse liver protein. Toxicol Lett 90:77-82
Cohen, S D; Pumford, N R; Khairallah, E A et al. (1997) Selective protein covalent binding and target organ toxicity. Toxicol Appl Pharmacol 143:1-12
Pumford, N R; Halmes, N C; Hinson, J A (1997) Covalent binding of xenobiotics to specific proteins in the liver. Drug Metab Rev 29:39-57
Hinson, J A; Roberts, D W; Halmes, N C et al. (1996) Immunochemical detection of drug-protein adducts in acetaminophen hepatotoxicity. Adv Exp Med Biol 387:47-55
Hinson, J A; Pumford, N R; Roberts, D W (1995) Mechanisms of acetaminophen toxicity: immunochemical detection of drug-protein adducts. Drug Metab Rev 27:73-92