Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM049242-04
Application #
2186807
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1993-06-01
Project End
1997-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Public Health Research Institute
Department
Type
DUNS #
City
Newark
State
NY
Country
United States
Zip Code
Sosunov, Vasily; Sosunova, Ekaterina; Mustaev, Arkady et al. (2003) Unified two-metal mechanism of RNA synthesis and degradation by RNA polymerase. EMBO J 22:2234-44
Sosunova, Ekaterina; Sosunov, Vasily; Kozlov, Maxim et al. (2003) Donation of catalytic residues to RNA polymerase active center by transcription factor Gre. Proc Natl Acad Sci U S A 100:15469-74
Mustaev, Arkadv; Zaychikov, Eugeny; Grachev, Mikhail et al. (2003) Strategies and methods of cross-linking of RNA polymerase active center. Methods Enzymol 371:191-206
Kazmierczak, K M; Davydova, E K; Mustaev, A A et al. (2002) The phage N4 virion RNA polymerase catalytic domain is related to single-subunit RNA polymerases. EMBO J 21:5815-23
Kuznedelov, Konstantin; Korzheva, Nataliya; Mustaev, Arkady et al. (2002) Structure-based analysis of RNA polymerase function: the largest subunit's rudder contributes critically to elongation complex stability and is not involved in the maintenance of RNA-DNA hybrid length. EMBO J 21:1369-78
Epshtein, Vitaliy; Mustaev, Arkady; Markovtsov, Vadim et al. (2002) Swing-gate model of nucleotide entry into the RNA polymerase active center. Mol Cell 10:623-34
Campbell, E A; Korzheva, N; Mustaev, A et al. (2001) Structural mechanism for rifampicin inhibition of bacterial rna polymerase. Cell 104:901-12
Korzheva, N; Mustaev, A; Kozlov, M et al. (2000) A structural model of transcription elongation. Science 289:619-25
Godson, G N; Mustaev, A A; Sun, W (1998) ATP cross-linked to Escherichia coli single-strand DNA-binding protein can be utilized by the catalytic center of primase as initiating nucleotide for primer RNA synthesis on phage G4oric template. Biochemistry 37:3810-7
Nudler, E; Gusarov, I; Avetissova, E et al. (1998) Spatial organization of transcription elongation complex in Escherichia coli. Science 281:424-8

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