Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
7R01GM049511-07
Application #
2187070
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1994-09-01
Project End
1998-08-31
Budget Start
1995-06-01
Budget End
1995-08-31
Support Year
7
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Agouron Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Yueh, Mei-Fei; Kawahara, Marleen; Raucy, Judy (2005) Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes. Toxicol In Vitro 19:275-87
Yueh, Mei-Fei; Kawahara, Marleen; Raucy, Judy (2005) High volume bioassays to assess CYP3A4-mediated drug interactions: induction and inhibition in a single cell line. Drug Metab Dispos 33:38-48
Murakami, Eisuke; Ray, Adrian S; Schinazi, Raymond F et al. (2004) Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of D- and L-D4FC-TP. Antiviral Res 62:57-64
Hirani, Vandana N; Raucy, Judy L; Lasker, Jerome M (2004) Conversion of the HIV protease inhibitor nelfinavir to a bioactive metabolite by human liver CYP2C19. Drug Metab Dispos 32:1462-7
Raucy, Judy L (2003) Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products. Drug Metab Dispos 31:533-9
Raucy, Judy L; Mueller, Lisa; Duan, Kui et al. (2002) Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes. J Pharmacol Exp Ther 302:475-82
Allen, S W; Mueller, L; Williams, S N et al. (2001) The use of a high-volume screening procedure to assess the effects of dietary flavonoids on human cyp1a1 expression. Drug Metab Dispos 29:1074-9
Wester, M R; Lasker, J M; Johnson, E F et al. (2000) CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes. Drug Metab Dispos 28:354-9
Lasker, J M; Wester, M R; Aramsombatdee, E et al. (1998) Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations. Arch Biochem Biophys 353:16-28
Jin, R; Koop, D R; Raucy, J L et al. (1998) Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4. Arch Biochem Biophys 359:89-98

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