Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM049573-07
Application #
2187115
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1992-12-01
Project End
2000-02-29
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Rochester
Department
Internal Medicine/Medicine
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Piekna-Przybylska, Dorota; Sullivan, Mark A; Sharma, Gaurav et al. (2014) U3 region in the HIV-1 genome adopts a G-quadruplex structure in its RNA and DNA sequence. Biochemistry 53:2581-93
Muchiri, John M; Li, Dongge; Dykes, Carrie et al. (2013) Efavirenz stimulates HIV-1 reverse transcriptase RNase H activity by a mechanism involving increased substrate binding and secondary cleavage activity. Biochemistry 52:4981-90
Piekna-Przybylska, Dorota; Sharma, Gaurav; Bambara, Robert A (2013) Mechanism of HIV-1 RNA dimerization in the central region of the genome and significance for viral evolution. J Biol Chem 288:24140-50
Amie, Sarah M; Daly, Michele B; Noble, Erin et al. (2013) Anti-HIV host factor SAMHD1 regulates viral sensitivity to nucleoside reverse transcriptase inhibitors via modulation of cellular deoxyribonucleoside triphosphate (dNTP) levels. J Biol Chem 288:20683-91
Nguyen, Laura A; Daddacha, Waaqo; Rigby, Sean et al. (2012) Altered strand transfer activity of a multiple-drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutant with a dipeptide fingers domain insertion. J Mol Biol 415:248-62
Muchiri, John M; Rigby, Sean T; Nguyen, Laura A et al. (2011) HIV-1 reverse transcriptase dissociates during strand transfer. J Mol Biol 412:354-64
Piekna-Przybylska, Dorota; Dykes, Carrie; Demeter, Lisa M et al. (2011) Sequences in the U3 region of human immunodeficiency virus 1 improve efficiency of minus strand transfer in infected cells. Virology 410:368-74
Shen, Wen; Gorelick, Robert J; Bambara, Robert A (2011) HIV-1 nucleocapsid protein increases strand transfer recombination by promoting dimeric G-quartet formation. J Biol Chem 286:29838-47
Piekna-Przybylska, Dorota; Bambara, Robert A (2011) Requirements for efficient minus strand strong-stop DNA transfer in human immunodeficiency virus 1. RNA Biol 8:230-6
Piekna-Przybylska, Dorota; DiChiacchio, Laura; Mathews, David H et al. (2010) A sequence similar to tRNA 3 Lys gene is embedded in HIV-1 U3-R and promotes minus-strand transfer. Nat Struct Mol Biol 17:83-9

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