I shall study the behavior of complex adaptive systems based on new mathematical tools including the analysis of model genomic systems linking about 100,000 genes and their products in a 'connectionist' parallel processing network. These models allow prediction of the large scale structure and behavior of genomic regulatory systems such as the numbers and stability of cell types and the overlap of gene expression patterns in diverse cell types. In addition, I shall continue work on models of morphogenesis. Experimental work is focused on generating libraries of partially stochastic genes and proteins and attempting to evolve novel functional proteins.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM049619-03
Application #
2187143
Study Section
Genetics Study Section (GEN)
Project Start
1993-08-01
Project End
1996-07-31
Budget Start
1995-08-01
Budget End
1996-07-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Santa Fe Institute
Department
Type
DUNS #
178044996
City
Santa Fe
State
NM
Country
United States
Zip Code
87501
Macready, W G; Siapas, A G; Kauffman, S A (1996) Criticality and parallelism in combinatorial optimization. Science 271:56-9