Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM050015-05S1
Application #
2698708
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1993-08-01
Project End
2001-07-31
Budget Start
1997-12-01
Budget End
1998-07-31
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Harvard University
Department
Genetics
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Wolkow, Tom D; Enoch, Tamar (2003) Fission yeast Rad26 responds to DNA damage independently of Rad3. BMC Genet 4:6
Wolkow, Tom D; Enoch, Tamar (2002) Fission yeast Rad26 is a regulatory subunit of the Rad3 checkpoint kinase. Mol Biol Cell 13:480-92
Kaur, R; Kostrub, C F; Enoch, T (2001) Structure-function analysis of fission yeast Hus1-Rad1-Rad9 checkpoint complex. Mol Biol Cell 12:3744-58
Weiss, R S; Enoch, T; Leder, P (2000) Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress. Genes Dev 14:1886-98
Chapman, C R; Evans, S T; Carr, A M et al. (1999) Requirement of sequences outside the conserved kinase domain of fission yeast Rad3p for checkpoint control. Mol Biol Cell 10:3223-38
Weiss, R S; Kostrub, C F; Enoch, T et al. (1999) Mouse Hus1, a homolog of the Schizosaccharomyces pombe hus1+ cell cycle checkpoint gene. Genomics 59:32-9
Moynihan, E B; Enoch, T (1999) Liz1p, a novel fission yeast membrane protein, is required for normal cell division when ribonucleotide reductase is inhibited. Mol Biol Cell 10:245-57
Humphrey, T; Enoch, T (1998) Sum1, a highly conserved WD-repeat protein, suppresses S-M checkpoint mutants and inhibits the osmotic stress cell cycle response in fission yeast. Genetics 148:1731-42
Kostrub, C F; Knudsen, K; Subramani, S et al. (1998) Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage. EMBO J 17:2055-66
Forbes, K C; Humphrey, T; Enoch, T (1998) Suppressors of cdc25p overexpression identify two pathways that influence the G2/M checkpoint in fission yeast. Genetics 150:1361-75

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