Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM050288-03
Application #
2188013
Study Section
Biochemistry Study Section (BIO)
Project Start
1994-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Medicine & Dentistry of NJ
Department
Biochemistry
Type
Schools of Medicine
DUNS #
622146454
City
Piscataway
State
NJ
Country
United States
Zip Code
08854

  Publications

Jacewicz, Agata; Chico, Lidia; Smith, Paul et al. (2015) Structural basis for recognition of intron branchpoint RNA by yeast Msl5 and selective effects of interfacial mutations on splicing of yeast pre-mRNAs. RNA 21:401-14
Schwer, Beate; Chang, Jonathan; Shuman, Stewart (2013) Structure-function analysis of the 5' end of yeast U1 snRNA highlights genetic interactions with the Msl5*Mud2 branchpoint-binding complex and other spliceosome assembly factors. Nucleic Acids Res 41:7485-500
Qiu, Zhicheng R; Chico, Lidia; Chang, Jonathan et al. (2012) Genetic interactions of hypomorphic mutations in the m7G cap-binding pocket of yeast nuclear cap binding complex: an essential role for Cbc2 in meiosis via splicing of MER3 pre-mRNA. RNA 18:1996-2011
Chang, Jonathan; Schwer, Beate; Shuman, Stewart (2012) Structure-function analysis and genetic interactions of the yeast branchpoint binding protein Msl5. Nucleic Acids Res 40:4539-52
Schwer, Beate; Erdjument-Bromage, Hediye; Shuman, Stewart (2011) Composition of yeast snRNPs and snoRNPs in the absence of trimethylguanosine caps reveals nuclear cap binding protein as a gained U1 component implicated in the cold-sensitivity of tgs1? cells. Nucleic Acids Res 39:6715-28
Qiu, Zhicheng R; Shuman, Stewart; Schwer, Beate (2011) An essential role for trimethylguanosine RNA caps in Saccharomyces cerevisiae meiosis and their requirement for splicing of SAE3 and PCH2 meiotic pre-mRNAs. Nucleic Acids Res 39:5633-46
Qiu, Zhicheng R; Schwer, Beate; Shuman, Stewart (2011) Defining the Mer1 and Nam8 meiotic splicing regulons by cDNA rescue. RNA 17:1648-54
Qiu, Zhicheng R; Schwer, Beate; Shuman, Stewart (2011) Determinants of Nam8-dependent splicing of meiotic pre-mRNAs. Nucleic Acids Res 39:3427-45
Schwer, Beate (2008) A conformational rearrangement in the spliceosome sets the stage for Prp22-dependent mRNA release. Mol Cell 30:743-54
Tanaka, Naoko; Aronova, Anna; Schwer, Beate (2007) Ntr1 activates the Prp43 helicase to trigger release of lariat-intron from the spliceosome. Genes Dev 21:2312-25

Showing the most recent 10 out of 25 publications